| Translation initiation factor IF-2, bacterial-like |
|---|
| Identifiers |
|---|
| Symbol | ? |
|---|
| InterPro | IPR000178 |
|---|
Bacterial initiation factor-2 is a bacterial initiation factor.[1]
IF2 binds to an initiator tRNA and controls the entry of tRNA onto the ribosome. IF2, bound to GTP, binds to the 30S P site. After associating with the 30S subunit, fMet-tRNAf binds to the IF2 then IF2 transfers the tRNA into the partial P site. When the 50S subunit joins, it hydrolyzes GTP to GDP and Pi, causing a conformational change in the IF2 that causes IF2 to release and allow the 70S ribosome to form.
Human mitochondria use a nuclear-encoded homolog, MTIF2, for translation initiation.[2]
References
- ^ Prokaryotic+Initiation+Factor-2 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- ^ D'Souza AR, Minczuk M (July 2018). "Mitochondrial transcription and translation: overview". Essays in Biochemistry. 62 (3): 309–320. doi:10.1042/EBC20170102. PMC 6056719. PMID 30030363.
Protein biosynthesis: translation (bacterial, archaeal, eukaryotic)
| Proteins | |
|---|
| Other concepts | |
|---|
