CCT8

Protein-coding gene in the species Homo sapiens
CCT8
Identifiers
AliasesCCT8, C21orf112, Cctq, D21S246, PRED71, chaperonin containing TCP1 subunit 8
External IDsOMIM: 617786; MGI: 107183; HomoloGene: 4802; GeneCards: CCT8; OMA:CCT8 - orthologs
Gene location (Human)
Chromosome 21 (human)
Chr.Chromosome 21 (human)[1]
Chromosome 21 (human)
Genomic location for CCT8
Genomic location for CCT8
Band21q21.3Start29,055,805 bp[1]
End29,073,797 bp[1]
Gene location (Mouse)
Chromosome 16 (mouse)
Chr.Chromosome 16 (mouse)[2]
Chromosome 16 (mouse)
Genomic location for CCT8
Genomic location for CCT8
Band16|16 C3.3Start87,280,214 bp[2]
End87,292,761 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • oocyte

  • gonad

  • secondary oocyte

  • epithelium of nasopharynx

  • embryo

  • ganglionic eminence

  • endothelial cell

  • germinal epithelium

  • Epithelium of choroid plexus

  • ventricular zone
Top expressed in
  • otic placode

  • otic vesicle

  • epiblast

  • mandibular prominence

  • maxillary prominence

  • saccule

  • somite

  • primitive streak

  • abdominal wall

  • tail of embryo
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • nucleotide binding
  • protein binding
  • ATP binding
  • protein folding chaperone activity
  • unfolded protein binding
  • cadherin binding
Cellular component
  • cell body
  • cytosol
  • centrosome
  • cell projection
  • cilium
  • nucleoplasm
  • microtubule organizing center
  • zona pellucida receptor complex
  • intermediate filament cytoskeleton
  • microtubule
  • extracellular exosome
  • cytoskeleton
  • cytoplasm
  • chaperonin-containing T-complex
  • extracellular region
  • secretory granule lumen
  • azurophil granule lumen
  • ficolin-1-rich granule lumen
Biological process
  • positive regulation of protein localization to Cajal body
  • positive regulation of establishment of protein localization to telomere
  • pore complex assembly
  • protein stabilization
  • positive regulation of telomere maintenance via telomerase
  • toxin transport
  • positive regulation of telomerase RNA localization to Cajal body
  • binding of sperm to zona pellucida
  • protein folding
  • 'de novo' protein folding
  • neutrophil degranulation
  • chaperone-mediated protein folding
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10694

12469

Ensembl

ENSG00000156261

ENSMUSG00000025613

UniProt

P50990

P42932

RefSeq (mRNA)

NM_006585
NM_001282907
NM_001282908
NM_001282909

NM_009840

RefSeq (protein)

NP_001269836
NP_001269837
NP_001269838
NP_006576

NP_033970

Location (UCSC)Chr 21: 29.06 – 29.07 MbChr 16: 87.28 – 87.29 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

T-complex protein 1 subunit theta is a protein that in humans is encoded by the CCT8 gene.[5][6] The CCT8 protein is a component of the TRiC complex.

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000156261 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025613 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kubota H, Hynes G, Willison K (Apr 1995). "The eighth Cct gene, Cctq, encoding the theta subunit of the cytosolic chaperonin containing TCP-1". Gene. 154 (2): 231–6. doi:10.1016/0378-1119(94)00880-2. PMID 7890169.
  6. ^ "Entrez Gene: CCT8 chaperonin containing TCP1, subunit 8 (theta)".

External links

Further reading

  • Nomura N, Miyajima N, Sazuka T, et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1". DNA Res. 1 (1): 27–35. doi:10.1093/dnares/1.1.27. PMID 7584026.
  • Nomura N, Miyajima N, Sazuka T, et al. (1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement)". DNA Res. 1 (1): 47–56. doi:10.1093/dnares/1.1.47. PMID 7584028.
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Yamazaki M, Ono A, Watanabe K, et al. (1996). "Nucleotide sequence surrounding the locus marker D21S246 on human chromosome 21". DNA Res. 2 (4): 187–9. doi:10.1093/dnares/2.4.187. PMID 8590283.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Scanlan MJ, Gordan JD, Williamson B, et al. (1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma". Int. J. Cancer. 83 (4): 456–64. doi:10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5. PMID 10508479.
  • Hynes GM, Willison KR (2000). "Individual subunits of the eukaryotic cytosolic chaperonin mediate interactions with binding sites located on subdomains of beta-actin". J. Biol. Chem. 275 (25): 18985–94. doi:10.1074/jbc.M910297199. PMID 10748209.
  • Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. Bibcode:2000Natur.405..311H. doi:10.1038/35012518. PMID 10830953.
  • Yokota S, Yanagi H, Yura T, Kubota H (2001). "Cytosolic chaperonin-containing t-complex polypeptide 1 changes the content of a particular subunit species concomitant with substrate binding and folding activities during the cell cycle". Eur. J. Biochem. 268 (17): 4664–73. doi:10.1046/j.1432-1327.2001.02393.x. PMID 11532003.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Imai Y, Soda M, Murakami T, et al. (2004). "A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death". J. Biol. Chem. 278 (51): 51901–10. doi:10.1074/jbc.M309655200. PMID 14532270.
  • Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
  • Wang L, Zhu YF, Guo XJ, et al. (2006). "A two-dimensional electrophoresis reference map of human ovary". J. Mol. Med. 83 (10): 812–21. doi:10.1007/s00109-005-0676-y. PMID 16021519. S2CID 6644433.
  • Hu YH, Warnatz HJ, Vanhecke D, et al. (2006). "Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins". BMC Genomics. 7: 155. doi:10.1186/1471-2164-7-155. PMC 1526728. PMID 16780588.
  • Kim SC, Sprung R, Chen Y, et al. (2006). "Substrate and functional diversity of lysine acetylation revealed by a proteomics survey". Mol. Cell. 23 (4): 607–18. doi:10.1016/j.molcel.2006.06.026. PMID 16916647.


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