COMMD1

Protein-coding gene in humans

COMMD1

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
2H2M

Identifiers

Aliases

COMMD1, C2orf5, MURR1, copper metabolism domain containing 1

External IDs

OMIM: 607238; MGI: 109474; HomoloGene: 17604; GeneCards: COMMD1; OMA:COMMD1 - orthologs

Gene location (Human)

Chr.	Chromosome 2 (human)^[1]

Band	2p15	Start	61,888,724 bp^[1]
Band	2p15	End	62,147,247 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 11 (mouse)^[2]

Band	11 A3.2\|11 14.22 cM	Start	22,846,136 bp^[2]
Band	11 A3.2\|11 14.22 cM	End	22,932,382 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

myocardium of left ventricle

tibialis anterior muscle

cardiac muscle tissue of right atrium

right ventricle

deltoid muscle

Skeletal muscle tissue of biceps brachii

right auricle

vena cava

skin of arm

mucosa of ileum

Top expressed in

embryo

embryo

spermatocyte

right kidney

ventricular zone

external carotid artery

intercostal muscle

epiblast

medullary collecting duct

internal carotid artery

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	protein homodimerization activity phosphatidylinositol-3,5-bisphosphate binding metal ion binding phosphatidylinositol-3,4-bisphosphate binding phosphatidic acid binding protein binding identical protein binding phosphatidylinositol-4,5-bisphosphate binding copper ion binding phosphatidylinositol-3,4,5-trisphosphate binding lipid binding
Cellular component	cytoplasm recycling endosome endosome membrane Cul2-RING ubiquitin ligase complex early endosome endosome membrane cytoplasmic vesicle nucleus nucleoplasm cytosol
Biological process	negative regulation of sodium ion transmembrane transport regulation of transcription, DNA-templated transcription, DNA-templated negative regulation of protein localization to cell surface plasma membrane to endosome transport regulation of proteasomal ubiquitin-dependent protein catabolic process protein transport negative regulation of NF-kappaB transcription factor activity positive regulation of protein ubiquitination Golgi to plasma membrane transport post-translational protein modification copper ion homeostasis protein ubiquitination
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


150684


17846

Ensembl


ENSG00000173163


ENSMUSG00000051355

UniProt


Q8N668


Q8K4M5

RefSeq (mRNA)


NM_152516 NM_001321781 NM_001321782 NM_001371765


NM_144514 NM_001361661

RefSeq (protein)


NP_001308710 NP_001308711 NP_689729 NP_001358694


NP_653097 NP_001348590

Location (UCSC)

Chr 2: 61.89 – 62.15 Mb

Chr 11: 22.85 – 22.93 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

COMM domain-containing protein 1 is a protein that is encoded by the COMMD1 gene in humans. It was originally regarded as Murr1 before being differentiated and renamed by Dr. Ezra Burstein's Lab^[5]^[6]^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000173163 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000051355 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nabetani A, Hatada I, Morisaki H, Oshimura M, Mukai T (Feb 1997). "Mouse U2af1-rs1 is a neomorphic imprinted gene". Mol Cell Biol. 17 (2): 789–98. doi:10.1128/mcb.17.2.789. PMC 231805. PMID 9001233.
^ van De Sluis B, Rothuizen J, Pearson PL, van Oost BA, Wijmenga C (Jan 2002). "Identification of a new copper metabolism gene by positional cloning in a purebred dog population". Hum Mol Genet. 11 (2): 165–73. doi:10.1093/hmg/11.2.165. PMID 11809725.
^ "Entrez Gene: COMMD1 copper metabolism (Murr1) domain containing 1".

External links

Human COMMD1 genome location and COMMD1 gene details page in the UCSC Genome Browser.

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Ganesh L, Burstein E, Guha-Niyogi A, et al. (2004). "The gene product Murr1 restricts HIV-1 replication in resting CD4+ lymphocytes". Nature. 426 (6968): 853–7. doi:10.1038/nature02171 (inactive 2024-04-25). hdl:2027.42/62709. PMID 14685242. S2CID 4344050.{{cite journal}}: CS1 maint: DOI inactive as of April 2024 (link)
Burstein E, Ganesh L, Dick RD, et al. (2004). "A novel role for XIAP in copper homeostasis through regulation of MURR1". EMBO J. 23 (1): 244–54. doi:10.1038/sj.emboj.7600031. PMC 1271669. PMID 14685266.
Stuehler B, Reichert J, Stremmel W, Schaefer M (2005). "Analysis of the human homologue of the canine copper toxicosis gene MURR1 in Wilson disease patients". J. Mol. Med. 82 (9): 629–34. doi:10.1007/s00109-004-0557-9. PMID 15205742. S2CID 8184776.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Burstein E, Hoberg JE, Wilkinson AS, et al. (2005). "COMMD proteins, a novel family of structural and functional homologs of MURR1". J. Biol. Chem. 280 (23): 22222–32. doi:10.1074/jbc.M501928200. PMID 15799966.
Coronado VA, Bonneville JA, Nazer H, et al. (2006). "COMMD1 (MURR1) as a candidate in patients with copper storage disease of undefined etiology". Clin. Genet. 68 (6): 548–51. doi:10.1111/j.1399-0004.2005.00524.x. PMID 16283886. S2CID 27815621.
Zhang Z, Joh K, Yatsuki H, et al. (2006). "Comparative analyses of genomic imprinting and CpG island-methylation in mouse Murr1 and human MURR1 loci revealed a putative imprinting control region in mice". Gene. 366 (1): 77–86. doi:10.1016/j.gene.2005.08.020. PMID 16305817.
de Bie P, van de Sluis B, Burstein E, et al. (2006). "Characterization of COMMD protein-protein interactions in NF-kappaB signalling". Biochem. J. 398 (1): 63–71. doi:10.1042/BJ20051664. PMC 1525016. PMID 16573520.
Sommerhalter M, Zhang Y, Rosenzweig AC (2007). "Solution structure of the COMMD1 N-terminal domain". J. Mol. Biol. 365 (3): 715–21. doi:10.1016/j.jmb.2006.10.030. PMC 2706016. PMID 17097678.
Maine GN, Mao X, Komarck CM, Burstein E (2007). "COMMD1 promotes the ubiquitination of NF-kappaB subunits through a cullin-containing ubiquitin ligase". EMBO J. 26 (2): 436–47. doi:10.1038/sj.emboj.7601489. PMC 1783443. PMID 17183367.