Etidocaine
Chemical compound
- AU: B1
administration
- N01BB07 (WHO)
- US: ℞-only
- N-(2,6-dimethylphenyl)-
2-(ethyl(propyl)amino)butanamide
- 36637-18-0 N
- 37497
- 2621
- DB08987 N
- 34400 Y
- I6CQM0F31V
- D04095 Y
- CHEBI:4904 Y
- ChEMBL492 Y
- DTXSID1023027
- Interactive image
- O=C(Nc1c(C)cccc1C)C(CC)N(CC)CCC
- InChI=1S/C17H28N2O/c1-6-12-19(8-3)15(7-2)17(20)18-16-13(4)10-9-11-14(16)5/h9-11,15H,6-8,12H2,1-5H3,(H,18,20) Y
- Key:VTUSIVBDOCDNHS-UHFFFAOYSA-N Y
Etidocaine, marketed under the trade name Duranest, is an amide-type local anesthetic given by injection during surgical procedures and labor and delivery. Etidocaine has a long duration of activity, and the main disadvantage of using during dentistry is increased bleeding during surgery.[1]
Synthesis
The amide reaction between 2,6-xylidine (1) and 2-bromobutyryl chloride [22118-12-3] (2) gives 2-Bromo-N-(2,6-Dimethylphenyl)Butanamide [53984-81-9] (3). Alkylation with N-Ethylpropylamine [20193-20-8] (4) gives Etidocaine (5).
References
External links
- Duranest (RxList)
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Aminobenzoic | |
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Benzoic | |
ArCO2- (not para-amino or Ph) |
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- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
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