FUT7

Protein-coding gene in the species Homo sapiens

FUT7

Identifiers

Aliases

FUT7, FucT-VII, fucosyltransferase 7

External IDs

OMIM: 602030; MGI: 107692; HomoloGene: 3296; GeneCards: FUT7; OMA:FUT7 - orthologs

Gene location (Human)

Chr.	Chromosome 9 (human)^[1]

Band	9q34.3	Start	137,030,174 bp^[1]
Band	9q34.3	End	137,032,088 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 2 (mouse)^[2]

Band	2\|2 A3	Start	25,313,279 bp^[2]
Band	2\|2 A3	End	25,316,386 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

olfactory bulb

beta cell

vena cava

body of tongue

cardia

parotid gland

lateral nuclear group of thalamus

triceps brachii muscle

subthalamic nucleus

pericardium

Top expressed in

granulocyte

embryo

embryo

CA3 field

bone marrow

thymus

lens

primary visual cortex

duodenum

dentate gyrus of hippocampal formation granule cell

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	transferase activity glycosyltransferase activity fucosyltransferase activity alpha-(1->3)-fucosyltransferase activity
Cellular component	integral component of membrane Golgi cisterna membrane membrane Golgi membrane Golgi apparatus
Biological process	leukocyte migration involved in immune response CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation L-fucose catabolic process fucosylation ceramide metabolic process protein glycosylation
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


2529


14347

Ensembl


ENSG00000180549


ENSMUSG00000036587

UniProt


Q11130


Q11131

RefSeq (mRNA)


NM_004479

NM_001177366 NM_001177367 NM_001289453 NM_001289454 NM_001289455
NM_001289456 NM_013524

RefSeq (protein)


NP_004470

NP_001170837 NP_001170838 NP_001276382 NP_001276383 NP_001276384
NP_001276385 NP_038552

Location (UCSC)

Chr 9: 137.03 – 137.03 Mb

Chr 2: 25.31 – 25.32 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Alpha-(1,3)-fucosyltransferase is an enzyme that in humans is encoded by the FUT7 gene.^[5]^[6]^[7]

Function

The sialyl Lewis x oligosaccharide determinant is an essential component of leukocyte counterreceptors for E-selectin- (MIM 131210) and P-selectin- (MIM 173610) mediated adhesions of leukocytes. This oligosaccharide molecule is displayed on the surfaces of granulocytes, monocytes, and natural killer cells. Formation of leukocyte adhesions to these selectins is an early and important step in the process that ultimately allows leukocytes to leave the vascular tree and become recruited into lymphoid tissues and sites of inflammation.[supplied by OMIM]^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000180549 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000036587 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Natsuka S, Gersten KM, Zenita K, Kannagi R, Lowe JB (June 1994). "Molecular cloning of a cDNA encoding a novel human leukocyte alpha-1,3-fucosyltransferase capable of synthesizing the sialyl Lewis x determinant". The Journal of Biological Chemistry. 269 (24): 16789–94. doi:10.1016/S0021-9258(19)89461-9. PMID 8207002.
^ Sasaki K, Kurata K, Funayama K, Nagata M, Watanabe E, Ohta S, Hanai N, Nishi T (May 1994). "Expression cloning of a novel alpha 1,3-fucosyltransferase that is involved in biosynthesis of the sialyl Lewis x carbohydrate determinants in leukocytes". The Journal of Biological Chemistry. 269 (20): 14730–7. doi:10.1016/S0021-9258(17)36686-3. PMID 8182079.
^ ^a ^b "Entrez Gene: FUT7 fucosyltransferase 7 (alpha (1,3) fucosyltransferase)".

Natsuka S, Gersten KM, Zenita K, Kannagi R, Lowe JB (August 1994). "Molecular cloning of a cDNA encoding a novel human leukocyte alpha-1,3-fucosyltransferase capable of synthesizing the sialyl Lewis x determinant". The Journal of Biological Chemistry. 269 (32): 20806. doi:10.1016/S0021-9258(17)32066-5. PMID 8051184.
Smith PL, Gersten KM, Petryniak B, Kelly RJ, Rogers C, Natsuka Y, Alford JA, Scheidegger EP, Natsuka S, Lowe JB (April 1996). "Expression of the alpha(1,3)fucosyltransferase Fuc-TVII in lymphoid aggregate high endothelial venules correlates with expression of L-selectin ligands". The Journal of Biological Chemistry. 271 (14): 8250–9. doi:10.1074/jbc.271.14.8250. PMID 8626519.
Le Marer N, Palcic MM, Clarke JL, Davies D, Skacel PO (April 1997). "Developmental regulation of alpha 1,3-fucosyltransferase expression in CD34 positive progenitors and maturing myeloid cells isolated from normal human bone marrow". Glycobiology. 7 (3): 357–65. doi:10.1093/glycob/7.3.357. PMID 9147044.
Mas E, Pasqualini E, Caillol N, El Battari A, Crotte C, Lombardo D, Sadoulet MO (June 1998). "Fucosyltransferase activities in human pancreatic tissue: comparative study between cancer tissues and established tumoral cell lines". Glycobiology. 8 (6): 605–13. doi:10.1093/glycob/8.6.605. PMID 9592127.
Bengtson P, Larson C, Lundblad A, Larson G, Påhlsson P (August 2001). "Identification of a missense mutation (G329A;Arg(110)--> GLN) in the human FUT7 gene". The Journal of Biological Chemistry. 276 (34): 31575–82. doi:10.1074/jbc.M104165200. PMID 11404359.
de Vries T, Yen TY, Joshi RK, Storm J, van Den Eijnden DH, Knegtel RM, Bunschoten H, Joziasse DH, Macher BA (May 2001). "Neighboring cysteine residues in human fucosyltransferase VII are engaged in disulfide bridges, forming small loop structures". Glycobiology. 11 (5): 423–32. doi:10.1093/glycob/11.5.423. PMID 11425803.
Roos C, Kolmer M, Mattila P, Renkonen R (February 2002). "Composition of Drosophila melanogaster proteome involved in fucosylated glycan metabolism". The Journal of Biological Chemistry. 277 (5): 3168–75. doi:10.1074/jbc.M107927200. PMID 11698403.
Zerfaoui M, Fukuda M, Langlet C, Mathieu S, Suzuki M, Lombardo D, El-Battari A (January 2002). "The cytosolic and transmembrane domains of the beta 1,6 N-acetylglucosaminyltransferase (C2GnT) function as a cis to medial/Golgi-targeting determinant". Glycobiology. 12 (1): 15–24. doi:10.1093/glycob/12.1.15. PMID 11825883.
Hiraiwa N, Yabuta T, Yoritomi K, Hiraiwa M, Tanaka Y, Suzuki T, Yoshida M, Kannagi R (May 2003). "Transactivation of the fucosyltransferase VII gene by human T-cell leukemia virus type 1 Tax through a variant cAMP-responsive element". Blood. 101 (9): 3615–21. doi:10.1182/blood-2002-07-2301. PMID 12506041.
Zisoulis DG, Kansas GS (September 2004). "H-Ras and phosphoinositide 3-kinase cooperate to induce alpha(1,3)-fucosyltransferase VII expression in Jurkat T cells". The Journal of Biological Chemistry. 279 (38): 39495–504. doi:10.1074/jbc.M407904200. PMID 15262995.
Miyashiro M, Furuya S, Fujishige K, Sugita T (November 2004). "Highly sensitive cell-based assay system to monitor the sialyl Lewis X biosynthesis mediated by alpha1-3 fucosyltransferase-VII". Biochemical and Biophysical Research Communications. 324 (1): 98–107. doi:10.1016/j.bbrc.2004.09.025. PMID 15464988.
Martinez M, Joffraud M, Giraud S, Baïsse B, Bernimoulin MP, Schapira M, Spertini O (February 2005). "Regulation of PSGL-1 interactions with L-selectin, P-selectin, and E-selectin: role of human fucosyltransferase-IV and -VII". The Journal of Biological Chemistry. 280 (7): 5378–90. doi:10.1074/jbc.M410899200. PMID 15579466.
Prorok-Hamon M, Notel F, Mathieu S, Langlet C, Fukuda M, El-Battari A (November 2005). "N-glycans of core2 beta(1,6)-N-acetylglucosaminyltransferase-I (C2GnT-I) but not those of alpha(1,3)-fucosyltransferase-VII (FucT-VII) are required for the synthesis of functional P-selectin glycoprotein ligand-1 (PSGL-1): effects on P-, L- and E-selectin binding". The Biochemical Journal. 391 (Pt 3): 491–502. doi:10.1042/BJ20050344. PMC 1276950. PMID 15926890.
Brown V, Brown RA, Ozinsky A, Hesselberth JR, Fields S (March 2006). "Binding specificity of Toll-like receptor cytoplasmic domains". European Journal of Immunology. 36 (3): 742–53. doi:10.1002/eji.200535158. PMC 2762736. PMID 16482509.
Wang QY, Zhang Y, Chen HJ, Shen ZH, Chen HL (January 2007). "Alpha 1,3-fucosyltransferase-VII regulates the signaling molecules of the insulin receptor pathway". The FEBS Journal. 274 (2): 526–38. doi:10.1111/j.1742-4658.2006.05599.x. PMID 17229154. S2CID 25250189.

Transferases: glycosyltransferases (EC 2.4)

2.4.1: Hexosyl-
transferases

Glucosyl-	Phosphorylase Starch Glycogen Cellobiose Myo- Glycogen synthase Debranching enzyme Branching enzyme 1,3-Beta-glucan synthase Ceramide glucosyltransferase N-glycosyltransferase
Galactosyl-	Lactose synthase B-N-acetylglucosaminyl-glycopeptide b-1,4-galactosyltransferase Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase (C1GALT1)
Glucuronosyl-	B3GAT1 B3GAT2 B3GAT3 UGT1A1 UGT1A3 UGT1A4 UGT1A5 UGT1A6 UGT1A7 UGT1A8 UGT1A9 UGT1A10 UGT2A1 UGT2A2 UGT2A3 UGT2B4 UGT2B7 UGT2B10 UGT2B11 UGT2B15 UGT2B17 UGT2B28 Hyaluronan synthase: HAS1 HAS2 HAS3
Fucosyl-	POFUT1 POFUT2 FUT1 FUT2 FUT3 FUT4 FUT5 FUT6 FUT7 FUT8 FUT9 FUT10 FUT11
Mannosyl-	Dolichyl-phosphate-mannose-protein mannosyltransferase POMT1 POMT2 DPM1 DPM3 ALG1 ALG2 ALG3 ALG6 ALG8 ALG9 ALG12

2.4.2: Pentosyl-
transferases

Ribose

ADP-ribosyltransferase	NAD⁺:diphthamide ADP-ribosyltransferase Diphtheria toxin Pseudomonas exotoxin NAD(P)⁺:arginine ADP-ribosyltransferase Pertussis toxin Cholera toxin Poly ADP ribose polymerase Sirtuin
Phosphoribosyltransferase	Adenine phosphoribosyltransferase Hypoxanthine-guanine phosphoribosyltransferase Uracil phosphoribosyltransferase Amidophosphoribosyltransferase
Other	Purine nucleoside phosphorylase: Thymidine phosphorylase ECGF1