KIF20A

Protein-coding gene in the species Homo sapiens
KIF20A
Identifiers
AliasesKIF20A, MKLP2, RAB6KIFL, kinesin family member 20A, RCM6
External IDsOMIM: 605664; MGI: 1201682; HomoloGene: 38093; GeneCards: KIF20A; OMA:KIF20A - orthologs
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for KIF20A
Genomic location for KIF20A
Band5q31.2Start138,178,719 bp[1]
End138,187,723 bp[1]
Gene location (Mouse)
Chromosome 18 (mouse)
Chr.Chromosome 18 (mouse)[2]
Chromosome 18 (mouse)
Genomic location for KIF20A
Genomic location for KIF20A
Band18 B1|18 18.69 cMStart34,757,666 bp[2]
End34,766,330 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • ventricular zone

  • gonad

  • oocyte

  • embryo

  • secondary oocyte

  • ganglionic eminence

  • testicle

  • stromal cell of endometrium

  • bone marrow

  • trabecular bone
Top expressed in
  • genital tubercle

  • spermatocyte

  • primitive streak

  • epiblast

  • abdominal wall

  • tail of embryo

  • maxillary prominence

  • mandibular prominence

  • zygote

  • somite
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • microtubule motor activity
  • nucleotide binding
  • transporter activity
  • microtubule binding
  • ATPase activity
  • protein binding
  • ATP binding
  • protein kinase binding
Cellular component
  • cytoplasm
  • Golgi apparatus
  • kinesin complex
  • spindle
  • midbody
  • microtubule
  • cytoskeleton
  • nucleoplasm
  • cleavage furrow
  • intercellular bridge
  • nucleus
Biological process
  • mitotic cytokinesis
  • microtubule-based movement
  • microtubule bundle formation
  • protein transport
  • septum digestion after cytokinesis
  • vesicle-mediated transport
  • cytokinesis
  • regulation of cytokinesis
  • midbody abscission
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

10112

19348

Ensembl

ENSG00000112984

ENSMUSG00000003779

UniProt

O95235

P97329

RefSeq (mRNA)

NM_005733

NM_001166406
NM_001166407
NM_009004

RefSeq (protein)

NP_005724

NP_001159878
NP_001159879
NP_033030

Location (UCSC)Chr 5: 138.18 – 138.19 MbChr 18: 34.76 – 34.77 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Kinesin-like protein KIF20A is a protein that in humans is encoded by the KIF20A gene.[5][6][7]

Interactions

KIF20A has been shown to interact with RAB6A.[8][9]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000112984 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000003779 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Miki H, Setou M, Kaneshiro K, Hirokawa N (June 2001). "All kinesin superfamily protein, KIF, genes in mouse and human". Proc Natl Acad Sci U S A. 98 (13): 7004–11. Bibcode:2001PNAS...98.7004M. doi:10.1073/pnas.111145398. PMC 34614. PMID 11416179.
  6. ^ Lai F, Fernald AA, Zhao N, Le Beau MM (July 2000). "cDNA cloning, expression pattern, genomic structure and chromosomal location of RAB6KIFL, a human kinesin-like gene". Gene. 248 (1–2): 117–25. doi:10.1016/S0378-1119(00)00135-9. PMID 10806357.
  7. ^ "Entrez Gene: KIF20A kinesin family member 20A".
  8. ^ Echard A, Jollivet F, Martinez O, Lacapère JJ, Rousselet A, Janoueix-Lerosey I, Goud B (January 1998). "Interaction of a Golgi-associated kinesin-like protein with Rab6". Science. 279 (5350): 580–5. Bibcode:1998Sci...279..580E. doi:10.1126/science.279.5350.580. PMID 9438855.
  9. ^ Echard A, Opdam FJ, de Leeuw HJ, Jollivet F, Savelkoul P, Hendriks W, Voorberg J, Goud B, Fransen JA (November 2000). "Alternative splicing of the human Rab6A gene generates two close but functionally different isoforms". Mol. Biol. Cell. 11 (11): 3819–33. doi:10.1091/mbc.11.11.3819. PMC 15039. PMID 11071909.

Further reading

  • Echard A, Jollivet F, Martinez O, Lacapère JJ, Rousselet A, Janoueix-Lerosey I, Goud B (1998). "Interaction of a Golgi-associated kinesin-like protein with Rab6". Science. 279 (5350): 580–5. Bibcode:1998Sci...279..580E. doi:10.1126/science.279.5350.580. PMID 9438855.
  • Horrevoets AJ, Fontijn RD, van Zonneveld AJ, de Vries CJ, ten Cate JW, Pannekoek H (1999). "Vascular endothelial genes that are responsive to tumor necrosis factor-alpha in vitro are expressed in atherosclerotic lesions, including inhibitor of apoptosis protein-1, stannin, and two novel genes". Blood. 93 (10): 3418–31. doi:10.1182/blood.V93.10.3418.410k23_3418_3431. PMID 10233894.
  • Opdam FJ, Echard A, Croes HJ, van den Hurk JA, van de Vorstenbosch RA, Ginsel LA, Goud B, Fransen JA (2000). "The small GTPase Rab6B, a novel Rab6 subfamily member, is cell-type specifically expressed and localised to the Golgi apparatus". J. Cell Sci. 113 (15): 2725–35. doi:10.1242/jcs.113.15.2725. PMID 10893188.
  • Hill E, Clarke M, Barr FA (2000). "The Rab6-binding kinesin, Rab6-KIFL, is required for cytokinesis". EMBO J. 19 (21): 5711–9. doi:10.1093/emboj/19.21.5711. PMC 305783. PMID 11060022.
  • Echard A, Opdam FJ, de Leeuw HJ, Jollivet F, Savelkoul P, Hendriks W, Voorberg J, Goud B, Fransen JA (2001). "Alternative Splicing of the Human Rab6A Gene Generates Two Close but Functionally Different Isoforms". Mol. Biol. Cell. 11 (11): 3819–33. doi:10.1091/mbc.11.11.3819. PMC 15039. PMID 11071909.
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
  • Nagura M, Nagao Y, Takita J, Igarashi T, LeGuern E, Hayashi Y (2003). "The kinesin superfamily protein Rab6KIFL is not involved in the pathophysiology of Charcot-Marie-Tooth disease type 4C". Int. J. Mol. Med. 11 (1): 45–7. doi:10.3892/ijmm.11.1.45. PMID 12469216.
  • Neef R, Preisinger C, Sutcliffe J, Kopajtich R, Nigg EA, Mayer TU, Barr FA (2003). "Phosphorylation of mitotic kinesin-like protein 2 by polo-like kinase 1 is required for cytokinesis". J. Cell Biol. 162 (5): 863–75. doi:10.1083/jcb.200306009. PMC 2172827. PMID 12939256.
  • Gruneberg U, Neef R, Honda R, Nigg EA, Barr FA (2004). "Relocation of Aurora B from centromeres to the central spindle at the metaphase to anaphase transition requires MKlp2". J. Cell Biol. 166 (2): 167–72. doi:10.1083/jcb.200403084. PMC 2172317. PMID 15263015.
  • Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
  • Taniuchi K, Nakagawa H, Nakamura T, Eguchi H, Ohigashi H, Ishikawa O, Katagiri T, Nakamura Y (2005). "Down-regulation of RAB6KIFL/KIF20A, a kinesin involved with membrane trafficking of discs large homologue 5, can attenuate growth of pancreatic cancer cell". Cancer Res. 65 (1): 105–12. doi:10.1158/0008-5472.105.65.1. PMID 15665285. S2CID 16616574.
  • Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
  • Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
  • Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

External links


  • v
  • t
  • e