MOCOS

Protein-coding gene in the species Homo sapiens
MOCOS
Identifiers
AliasesMOCOS, hMCS, MCS, MOS, molybdenum cofactor sulfurase
External IDsOMIM: 613274; MGI: 1915841; HomoloGene: 9931; GeneCards: MOCOS; OMA:MOCOS - orthologs
Gene location (Human)
Chromosome 18 (human)
Chr.Chromosome 18 (human)[1]
Chromosome 18 (human)
Genomic location for MOCOS
Genomic location for MOCOS
Band18q12.2Start36,187,497 bp[1]
End36,272,157 bp[1]
Gene location (Mouse)
Chromosome 18 (mouse)
Chr.Chromosome 18 (mouse)[2]
Chromosome 18 (mouse)
Genomic location for MOCOS
Genomic location for MOCOS
Band18|18 A2Start24,786,748 bp[2]
End24,834,632 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • secondary oocyte

  • right lobe of liver

  • palpebral conjunctiva

  • right adrenal gland

  • right adrenal cortex

  • jejunal mucosa

  • left adrenal gland

  • left adrenal cortex

  • buccal mucosa cell

  • duodenum
Top expressed in
  • granulocyte

  • left lobe of liver

  • esophagus

  • primary oocyte

  • jejunum

  • gastrula

  • respiratory epithelium

  • olfactory system

  • olfactory epithelium

  • duodenum
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • transferase activity
  • molybdenum ion binding
  • pyridoxal phosphate binding
  • protein binding
  • catalytic activity
  • Mo-molybdopterin cofactor sulfurase activity
  • molybdenum cofactor sulfurtransferase activity
  • lyase activity
Cellular component
  • cytosol
  • cellular component
Biological process
  • Mo-molybdopterin cofactor biosynthetic process
  • molybdopterin cofactor biosynthetic process
  • molybdopterin cofactor metabolic process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

55034

68591

Ensembl

ENSG00000075643

ENSMUSG00000039616

UniProt

Q96EN8

Q14CH1

RefSeq (mRNA)

NM_017947

NM_026779

RefSeq (protein)

NP_060417

NP_081055

Location (UCSC)Chr 18: 36.19 – 36.27 MbChr 18: 24.79 – 24.83 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Molybdenum cofactor sulfurase is an enzyme that in humans is encoded by the MOCOS gene.[5][6]

MOCOS sulfurates the molybdenum cofactor of xanthine dehydrogenase (XDH) and aldehyde oxidase (AOX1), which is required for their enzymatic activities.[5]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000075643 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039616 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Ichida K, Matsumura T, Sakuma R, Hosoya T, Nishino T (April 2001). "Mutation of human molybdenum cofactor sulfurase gene is responsible for classical xanthinuria type II". Biochemical and Biophysical Research Communications. 282 (5): 1194–200. doi:10.1006/bbrc.2001.4719. PMID 11302742.
  6. ^ "Entrez Gene: MOCOS molybdenum cofactor sulfurase".

Further reading

  • Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Yamamoto T, Moriwaki Y, Takahashi S, Tsutsumi Z, Tuneyoshi K, Matsui K, et al. (November 2003). "Identification of a new point mutation in the human molybdenum cofactor sulferase gene that is responsible for xanthinuria type II". Metabolism. 52 (11): 1501–4. doi:10.1016/s0026-0495(03)00272-5. PMID 14624414.
  • Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (October 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
  • Peretz H, Naamati MS, Levartovsky D, Lagziel A, Shani E, Horn I, et al. (May 2007). "Identification and characterization of the first mutation (Arg776Cys) in the C-terminal domain of the Human Molybdenum Cofactor Sulfurase (HMCS) associated with type II classical xanthinuria". Molecular Genetics and Metabolism. 91 (1): 23–9. doi:10.1016/j.ymgme.2007.02.005. PMID 17368066.
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