PICK1

Protein-coding gene in the species Homo sapiens

PICK1

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
2GZV

Identifiers

Aliases

PICK1, PICK, PRKCABP, protein interacting with PRKCA 1

External IDs

OMIM: 605926; MGI: 894645; HomoloGene: 7470; GeneCards: PICK1; OMA:PICK1 - orthologs

Gene location (Human)

Chr.	Chromosome 22 (human)^[1]

Band	22q13.1	Start	38,056,311 bp^[1]
Band	22q13.1	End	38,075,701 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 15 (mouse)^[2]

Band	15\|15 E1	Start	79,113,373 bp^[2]
Band	15\|15 E1	End	79,133,684 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

anterior pituitary

right uterine tube

gastric mucosa

body of pancreas

right lobe of thyroid gland

minor salivary glands

left lobe of thyroid gland

skin of abdomen

right lung

sural nerve

Top expressed in

spermatid

spermatocyte

superior frontal gyrus

crypt of lieberkuhn of small intestine

extensor digitorum longus muscle

proximal tubule

cerebellar cortex

masseter muscle

soleus muscle

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	protein domain specific binding Arp2/3 complex binding metal ion binding actin filament binding protein C-terminus binding protein binding identical protein binding enzyme binding actin binding signaling receptor binding G protein-coupled receptor binding protein kinase C binding phospholipid binding
Cellular component	cytoplasm endocytic vesicle membrane postsynaptic membrane Golgi apparatus postsynaptic density membrane plasma membrane synapse cell junction perinuclear region of cytoplasm neuron projection cytoskeleton presynaptic membrane mitochondrion cytosol aggresome synaptic vesicle trans-Golgi network membrane postsynaptic early endosome
Biological process	cellular response to glucose starvation glial cell development retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum positive regulation of receptor internalization neuronal ion channel clustering regulation of Arp2/3 complex-mediated actin nucleation monoamine transport receptor clustering DNA methylation involved in gamete generation negative regulation of Arp2/3 complex-mediated actin nucleation dendritic spine organization dendritic spine maintenance protein phosphorylation protein kinase C-activating G protein-coupled receptor signaling pathway long-term depression cellular response to decreased oxygen levels DNA methylation involved in embryo development intracellular protein transport
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


9463


18693

Ensembl


ENSG00000100151


ENSMUSG00000068206

UniProt


Q9NRD5


Q62083

RefSeq (mRNA)


NM_001039583 NM_001039584 NM_012407


NM_001045558 NM_008837

RefSeq (protein)

NP_001034672 NP_001034673 NP_036539 NP_001034672.1 NP_001034673.1
NP_036539.1


n/a

Location (UCSC)

Chr 22: 38.06 – 38.08 Mb

Chr 15: 79.11 – 79.13 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Protein Interacting with C Kinase - 1 is a protein that in humans is encoded by the PICK1 gene.^[5]^[6]

Function

The protein encoded by this gene contains a PDZ domain, through which it interacts with protein kinase C, alpha (PRKCA). This protein may function as an adaptor that binds to and organizes the subcellular localization of a variety of membrane proteins. It has been shown to interact with multiple glutamate receptor subtypes, monoamine plasma membrane transporters, as well as non-voltage gated sodium channels, and may target PRKCA to these membrane proteins and thus regulate their distribution and function. This protein has also been found to act as an anchoring protein that specifically targets PRKCA to mitochondria in a ligand-specific manner. Three transcript variants encoding the same protein have been found for this gene.^[7]

Interactions

PICK1 has been shown to interact with:

ACCN2,^[8]^[9]
BNC1,^[9]
Dopamine transporter,^[10]
GRIA2,^[11]
GRIA3,^[11]
GRIA4,^[11]
GRIK1,^[12]
GRIK2,^[12]
GRIK3,^[11]
HER2/neu,^[13]
Metabotropic glutamate receptor 3,^[11] and
Metabotropic glutamate receptor 7.^[14]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000100151 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000068206 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Dev KK, Nishimune A, Henley JM, Nakanishi S (July 1999). "The protein kinase C alpha binding protein PICK1 interacts with short but not long form alternative splice variants of AMPA receptor subunits". Neuropharmacology. 38 (5): 635–44. doi:10.1016/S0028-3908(98)00230-5. PMID 10340301. S2CID 20472140.
^ Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (December 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
^ "Entrez Gene: PICK1 protein interacting with PRKCA 1".
^ Leonard AS, Yermolaieva O, Hruska-Hageman A, Askwith CC, Price MP, Wemmie JA, Welsh MJ (February 2003). "cAMP-dependent protein kinase phosphorylation of the acid-sensing ion channel-1 regulates its binding to the protein interacting with C-kinase-1". Proc. Natl. Acad. Sci. U.S.A. 100 (4): 2029–34. Bibcode:2003PNAS..100.2029L. doi:10.1073/pnas.252782799. PMC 149953. PMID 12578970.
^ ^a ^b Hruska-Hageman AM, Wemmie JA, Price MP, Welsh MJ (February 2002). "Interaction of the synaptic protein PICK1 (protein interacting with C kinase 1) with the non-voltage gated sodium channels BNC1 (brain Na+ channel 1) and ASIC (acid-sensing ion channel)". Biochem. J. 361 (Pt 3): 443–50. doi:10.1042/0264-6021:3610443. PMC 1222326. PMID 11802773.
^ Torres GE, Yao WD, Mohn AR, Quan H, Kim KM, Levey AI, Staudinger J, Caron MG (April 2001). "Functional interaction between monoamine plasma membrane transporters and the synaptic PDZ domain-containing protein PICK1". Neuron. 30 (1): 121–34. doi:10.1016/s0896-6273(01)00267-7. PMID 11343649.
^ ^a ^b ^c ^d ^e Hirbec H, Perestenko O, Nishimune A, Meyer G, Nakanishi S, Henley JM, Dev KK (May 2002). "The PDZ proteins PICK1, GRIP, and syntenin bind multiple glutamate receptor subtypes. Analysis of PDZ binding motifs" (PDF). J. Biol. Chem. 277 (18): 15221–4. doi:10.1074/jbc.C200112200. PMID 11891216.
^ ^a ^b Hirbec H, Francis JC, Lauri SE, Braithwaite SP, Coussen F, Mulle C, Dev KK, Coutinho V, Meyer G, Isaac JT, Collingridge GL, Henley JM, Couthino V (February 2003). "Rapid and differential regulation of AMPA and kainate receptors at hippocampal mossy fibre synapses by PICK1 and GRIP". Neuron. 37 (4): 625–38. doi:10.1016/s0896-6273(02)01191-1. PMC 3314502. PMID 12597860.
^ Jaulin-Bastard F, Saito H, Le Bivic A, Ollendorff V, Marchetto S, Birnbaum D, Borg JP (May 2001). "The ERBB2/HER2 receptor differentially interacts with ERBIN and PICK1 PSD-95/DLG/ZO-1 domain proteins". J. Biol. Chem. 276 (18): 15256–63. doi:10.1074/jbc.M010032200. PMID 11278603.
^ Dev KK, Nakajima Y, Kitano J, Braithwaite SP, Henley JM, Nakanishi S (October 2000). "PICK1 interacts with and regulates PKC phosphorylation of mGLUR7". J. Neurosci. 20 (19): 7252–7. doi:10.1523/JNEUROSCI.20-19-07252.2000. PMC 6772771. PMID 11007882.