PRPF4B

Protein-coding gene in the species Homo sapiens
PRPF4B
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

4IAN, 4IFC, 4IIR, 4IJP

Identifiers
AliasesPRPF4B, PR4H, PRP4, PRP4H, PRP4K, dJ1013A10.1, pre-mRNA processing factor 4B
External IDsOMIM: 602338; MGI: 109584; HomoloGene: 134085; GeneCards: PRPF4B; OMA:PRPF4B - orthologs
Gene location (Human)
Chromosome 6 (human)
Chr.Chromosome 6 (human)[1]
Chromosome 6 (human)
Genomic location for PRPF4B
Genomic location for PRPF4B
Band6p25.2Start4,021,267 bp[1]
End4,064,983 bp[1]
Gene location (Mouse)
Chromosome 13 (mouse)
Chr.Chromosome 13 (mouse)[2]
Chromosome 13 (mouse)
Genomic location for PRPF4B
Genomic location for PRPF4B
Band13|13 A3.3Start34,875,302 bp[2]
End34,906,064 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • endothelial cell

  • Epithelium of choroid plexus

  • mucosa of paranasal sinus

  • Achilles tendon

  • epithelium of nasopharynx

  • ventricular zone

  • left ovary

  • body of uterus

  • right ovary

  • right uterine tube
Top expressed in
  • fossa

  • condyle

  • genital tubercle

  • Paneth cell

  • tail of embryo

  • lobe of cerebellum

  • cerebellar vermis

  • substantia nigra

  • otic placode

  • saccule
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • kinase activity
  • transferase activity
  • protein kinase activity
  • protein serine/threonine kinase activity
  • nucleotide binding
  • protein binding
  • ATP binding
  • cyclin-dependent protein serine/threonine kinase activity
  • RNA binding
Cellular component
  • catalytic step 2 spliceosome
  • spliceosomal complex
  • nucleus
  • chromosome
  • nuclear speck
Biological process
  • mRNA splicing, via spliceosome
  • protein phosphorylation
  • mRNA processing
  • RNA splicing
  • phosphorylation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

8899

19134

Ensembl

ENSG00000112739

ENSMUSG00000021413

UniProt

Q13523

Q61136

RefSeq (mRNA)

NM_003913
NM_176800

NM_013830

RefSeq (protein)

NP_003904

NP_038858

Location (UCSC)Chr 6: 4.02 – 4.06 MbChr 13: 34.88 – 34.91 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Serine/threonine-protein kinase PRP4 homolog is an enzyme that in humans is encoded by the PRPF4B gene.[5][6][7]

Pre-mRNA splicing occurs in two sequential transesterification steps, and the protein encoded by this gene is thought to be involved in pre-mRNA splicing and in signal transduction. This protein belongs to a kinase family that includes serine/arginine-rich protein-specific kinases and cyclin-dependent kinases (CDKs). This protein is regarded as a CDK-like kinase (Clk) with homology to mitogen-activated protein kinases (MAPKs).[7]

Interactions

PRPF4B has been shown to interact with Pinin.[8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000112739 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021413 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Aug 1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (1): 31–9. doi:10.1093/dnares/5.1.31. PMID 9628581.
  6. ^ Kojima T, Zama T, Wada K, Onogi H, Hagiwara M (Aug 2001). "Cloning of human PRP4 reveals interaction with Clk1". J Biol Chem. 276 (34): 32247–56. doi:10.1074/jbc.M103790200. PMID 11418604.
  7. ^ a b "Entrez Gene: PRPF4B PRP4 pre-mRNA processing factor 4 homolog B (yeast)".
  8. ^ Dellaire, Graham; Makarov Evgeny M; Cowger Jeff J M; Longman Dasa; Sutherland Heidi G E; Lührmann Reinhard; Torchia Joseph; Bickmore Wendy A (Jul 2002). "Mammalian PRP4 Kinase Copurifies and Interacts with Components of Both the U5 snRNP and the N-CoR Deacetylase Complexes". Mol. Cell. Biol. 22 (14). United States: 5141–56. doi:10.1128/MCB.22.14.5141-5156.2002. hdl:11858/00-001M-0000-0029-BC76-A. ISSN 0270-7306. PMC 139773. PMID 12077342.

Further reading

  • Schultz SJ, Nigg EA (1994). "Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans". Cell Growth Differ. 4 (10): 821–30. PMID 8274451.
  • Gross T, Lützelberger M, Weigmann H, et al. (1997). "Functional analysis of the fission yeast Prp4 protein kinase involved in pre-mRNA splicing and isolation of a putative mammalian homologue". Nucleic Acids Res. 25 (5): 1028–35. doi:10.1093/nar/25.5.1028. PMC 146536. PMID 9102632.
  • Huang Y, Deng T, Winston BW (2000). "Characterization of hPRP4 kinase activation: potential role in signaling". Biochem. Biophys. Res. Commun. 271 (2): 456–63. doi:10.1006/bbrc.2000.2651. PMID 10799319.
  • Jurica MS, Licklider LJ, Gygi SR, et al. (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA. 8 (4): 426–39. doi:10.1017/S1355838202021088. PMC 1370266. PMID 11991638.
  • Dellaire G, Makarov EM, Cowger JJ, et al. (2002). "Mammalian PRP4 Kinase Copurifies and Interacts with Components of Both the U5 snRNP and the N-CoR Deacetylase Complexes". Mol. Cell. Biol. 22 (14): 5141–56. doi:10.1128/MCB.22.14.5141-5156.2002. PMC 139773. PMID 12077342.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Bennett EM, Lever AM, Allen JF (2004). "Human Immunodeficiency Virus Type 2 Gag Interacts Specifically with PRP4, a Serine-Threonine Kinase, and Inhibits Phosphorylation of Splicing Factor SF2". J. Virol. 78 (20): 11303–12. doi:10.1128/JVI.78.20.11303-11312.2004. PMC 521795. PMID 15452250.
  • Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
  • Zhang Y, Wolf-Yadlin A, Ross PL, et al. (2005). "Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules". Mol. Cell. Proteomics. 4 (9): 1240–50. doi:10.1074/mcp.M500089-MCP200. PMID 15951569.
  • Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
  • Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
  • Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  • Huang B, Ahn YT, McPherson L, et al. (2007). "Interaction of PRP4 with Krüppel-Like Factor 13 Regulates CCL5 Transcription". J. Immunol. 178 (11): 7081–7. doi:10.4049/jimmunol.178.11.7081. PMC 2674583. PMID 17513757.
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