RAB35

Protein-coding gene in the species Homo sapiens
RAB35
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

3TW8

Identifiers
AliasesRAB35, H-ray, RAB1C, RAY, member RAS oncogene family
External IDsOMIM: 604199; MGI: 1924657; HomoloGene: 21361; GeneCards: RAB35; OMA:RAB35 - orthologs
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for RAB35
Genomic location for RAB35
Band12q24.23Start120,095,099 bp[1]
End120,117,502 bp[1]
Gene location (Mouse)
Chromosome 5 (mouse)
Chr.Chromosome 5 (mouse)[2]
Chromosome 5 (mouse)
Genomic location for RAB35
Genomic location for RAB35
Band5|5 FStart115,769,967 bp[2]
End115,785,795 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • granulocyte

  • stromal cell of endometrium

  • skin of leg

  • skin of abdomen

  • monocyte

  • mucosa of esophagus

  • ganglionic eminence

  • left uterine tube

  • ectocervix

  • right coronary artery
Top expressed in
  • granulocyte

  • placenta

  • ganglionic eminence

  • dentate gyrus of hippocampal formation granule cell

  • hippocampus proper

  • primary visual cortex

  • striatum of neuraxis

  • lip

  • white adipose tissue

  • cerebellum
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • nucleotide binding
  • GDP binding
  • GTP binding
  • protein binding
  • phosphatidylinositol-4,5-bisphosphate binding
  • GTPase activity
Cellular component
  • endosome
  • membrane
  • melanosome
  • clathrin-coated endocytic vesicle
  • plasma membrane
  • mitochondrion
  • cell projection membrane
  • intercellular bridge
  • clathrin-coated pit
  • endosome membrane
  • extracellular exosome
  • cytoplasmic vesicle
  • clathrin-coated vesicle
  • cytosol
  • clathrin-coated vesicle membrane
  • recycling endosome membrane
  • anchored component of synaptic vesicle membrane
  • Golgi membrane
  • intracellular anatomical structure
Biological process
  • protein localization
  • cellular response to nerve growth factor stimulus
  • antigen processing and presentation
  • cytokinesis
  • endosomal transport
  • plasma membrane to endosome transport
  • endocytic recycling
  • protein transport
  • protein localization to endosome
  • neuron projection development
  • transport
  • mitotic cytokinesis
  • intracellular protein transport
  • Rab protein signal transduction
  • small GTPase mediated signal transduction
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

11021

77407

Ensembl

ENSG00000111737

ENSMUSG00000029518

UniProt

Q15286

Q6PHN9

RefSeq (mRNA)

NM_001167606
NM_006861

NM_198163

RefSeq (protein)

NP_001161078
NP_006852

NP_937806

Location (UCSC)Chr 12: 120.1 – 120.12 MbChr 5: 115.77 – 115.79 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ras-related protein Rab-35 is a protein that in humans is encoded by the RAB35 gene.[5] This GTPase participates in the traffic of recycling endosomes toward the plasma membrane,[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000111737 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029518 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: RAB35 RAB35, member RAS oncogene family".
  6. ^ Kouranti I, Sachse M, Arouche N, Goud B, Echard A (Sep 2006). "Rab35 regulates an endocytic recycling pathway essential for the terminal steps of cytokinesis". Current Biology. 16 (17): 1719–25. Bibcode:2006CBio...16.1719K. doi:10.1016/j.cub.2006.07.020. PMID 16950109. S2CID 17407979.

Further reading

  • Chi A, Valencia JC, Hu ZZ, Watabe H, Yamaguchi H, Mangini NJ, Huang H, Canfield VA, Cheng KC, Yang F, Abe R, Yamagishi S, Shabanowitz J, Hearing VJ, Wu C, Appella E, Hunt DF (Nov 2006). "Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes". Journal of Proteome Research. 5 (11): 3135–44. doi:10.1021/pr060363j. PMID 17081065.
  • Kouranti I, Sachse M, Arouche N, Goud B, Echard A (Sep 2006). "Rab35 regulates an endocytic recycling pathway essential for the terminal steps of cytokinesis". Current Biology. 16 (17): 1719–25. Bibcode:2006CBio...16.1719K. doi:10.1016/j.cub.2006.07.020. PMID 16950109. S2CID 17407979.
  • Abe Y, Takeuchi T, Imai Y, Murase R, Kamei Y, Fujibuchi T, Matsumoto S, Ueda N, Ogasawara M, Shigemoto K, Kito K (May 2006). "A Small Ras-like protein Ray/Rab1c modulates the p53-regulating activity of PRPK". Biochemical and Biophysical Research Communications. 344 (1): 377–85. doi:10.1016/j.bbrc.2006.03.071. PMID 16600182.
  • Zhu AX, Zhao Y, Flier JS (Dec 1994). "Molecular cloning of two small GTP-binding proteins from human skeletal muscle". Biochemical and Biophysical Research Communications. 205 (3): 1875–82. doi:10.1006/bbrc.1994.2889. PMID 7811277.
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