RAB3C

Protein-coding gene in the species Homo sapiens
RAB3C
Identifiers
AliasesRAB3C, member RAS oncogene family
External IDsOMIM: 612829; MGI: 1914545; HomoloGene: 23420; GeneCards: RAB3C; OMA:RAB3C - orthologs
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for RAB3C
Genomic location for RAB3C
Band5q11.2Start58,582,221 bp[1]
End58,859,394 bp[1]
Gene location (Mouse)
Chromosome 13 (mouse)
Chr.Chromosome 13 (mouse)[2]
Chromosome 13 (mouse)
Genomic location for RAB3C
Genomic location for RAB3C
Band13|13 D2.1Start110,190,721 bp[2]
End110,417,530 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • lateral nuclear group of thalamus

  • Pars compacta

  • pars reticulata

  • Brodmann area 46

  • middle temporal gyrus

  • superior frontal gyrus

  • Brodmann area 23

  • superior vestibular nucleus

  • islet of Langerhans

  • postcentral gyrus
Top expressed in
  • medial dorsal nucleus

  • ventral tegmental area

  • medial geniculate nucleus

  • subiculum

  • lateral geniculate nucleus

  • superior colliculus

  • dorsomedial hypothalamic nucleus

  • paraventricular nucleus of hypothalamus

  • dorsal tegmental nucleus

  • anterior amygdaloid area
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • nucleotide binding
  • GTP binding
  • myosin V binding
  • protein binding
  • GTP-dependent protein binding
  • GTPase activity
Cellular component
  • perinuclear region of cytoplasm
  • vesicle
  • cytosol
  • plasma membrane
  • membrane
  • synaptic vesicle
  • anchored component of synaptic vesicle membrane
  • endosome
Biological process
  • regulation of exocytosis
  • protein transport
  • antigen processing and presentation
  • intracellular protein transport
  • vesicle docking involved in exocytosis
  • protein secretion
  • Rab protein signal transduction
  • protein localization to plasma membrane
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

115827

67295

Ensembl

ENSG00000152932

ENSMUSG00000021700

UniProt

Q96E17

P62823

RefSeq (mRNA)

NM_138453
NM_001317915

NM_023852
NM_001360099

RefSeq (protein)

NP_001304844
NP_612462

NP_076341
NP_001347028

Location (UCSC)Chr 5: 58.58 – 58.86 MbChr 13: 110.19 – 110.42 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ras-related protein Rab-3C is a protein that in humans is encoded by the RAB3C gene.[5][6]

Interactions

Rab3C has been shown to interact with ZWINT.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000152932 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021700 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Cheng H, Ma Y, Ni X, Jiang M, Luo Y, Ying K, Xie Y, Ma Y (Aug 2002). "Cloning, mapping, and characterization of the human Rab3C gene". Biochemical Genetics. 40 (7–8): 263–72. doi:10.1023/A:1019834901190. PMID 12296628. S2CID 10653465.
  6. ^ "Entrez Gene: RAB3C RAB3C, member RAS oncogene family".
  7. ^ van Vlijmen T, Vleugel M, Evers M, Mohammed S, Wulf PS, Heck AJ, Hoogenraad CC, van der Sluijs P (Aug 2008). "A unique residue in rab3c determines the interaction with novel binding protein Zwint-1". FEBS Letters. 582 (19): 2838–42. doi:10.1016/j.febslet.2008.07.012. PMID 18625232. S2CID 30206840.

Further reading

  • Matsumoto M, Miki T, Shibasaki T, Kawaguchi M, Shinozaki H, Nio J, Saraya A, Koseki H, Miyazaki M, Iwanaga T, Seino S (Jun 2004). "Noc2 is essential in normal regulation of exocytosis in endocrine and exocrine cells". Proceedings of the National Academy of Sciences of the United States of America. 101 (22): 8313–8. Bibcode:2004PNAS..101.8313M. doi:10.1073/pnas.0306709101. PMC 420391. PMID 15159548.
  • Fukuda M (Apr 2003). "Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2". The Journal of Biological Chemistry. 278 (17): 15373–80. doi:10.1074/jbc.M212341200. PMID 12578829.
  • Schlüter OM, Khvotchev M, Jahn R, Südhof TC (Oct 2002). "Localization versus function of Rab3 proteins. Evidence for a common regulatory role in controlling fusion". The Journal of Biological Chemistry. 277 (43): 40919–29. doi:10.1074/jbc.M203704200. PMID 12167638.
  • Uphues I, Chern Y, Eckel J (Dec 1995). "Insulin-dependent translocation of the small GTP-binding protein rab3C in cardiac muscle: studies on insulin-resistant Zucker rats". FEBS Letters. 377 (2): 109–12. doi:10.1016/0014-5793(95)01315-6. PMID 8543030. S2CID 27119138.


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