SKF-89,145

Chemical compound

SKF-89,145
Identifiers

IUPAC name 4-(6-methyl-5,7-dihydro-4H-thieno[2,3-c]pyridin-4-yl)benzene-1,2-diol
PubChem CID	10061214
ChemSpider	8236766
ChEMBL	ChEMBL1591046
CompTox Dashboard (EPA)	DTXSID201017993
Chemical and physical data
Formula	C₁₄H₁₅NO₂S
Molar mass	261.34 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES Oc1ccc(cc1O)C2CN(C)Cc3sccc23
InChI InChI=1S/C14H15NO2S/c1-15-7-11(10-4-5-18-14(10)8-15)9-2-3-12(16)13(17)6-9/h2-6,11,16-17H,7-8H2,1H3 Key:SYHALWYYSDMSLE-UHFFFAOYSA-N
(verify)

SKF-89,145 is a drug which acts as a dopamine agonist selective for the D₁ subtype. The N-desmethyl derivative SKF-89,626 is also a selective D₁ agonist with similar potency and selectivity to SKF 89,145.^[1]

References

^ O'Boyle KM, Waddington JL (December 1987). "New substituted 1-phenyl-3-benzazepine analogues of SK&F 38393 and N-methyl-thienopyridine analogues of dihydroxynomifensine with selective affinity for the D-1 dopamine receptor in human post-mortem brain". Neuropharmacology. 26 (12): 1807–10. doi:10.1016/0028-3908(87)90139-0. PMID 3501846. S2CID 34415106.

Dopamine receptor modulators

D₁-like

Agonists	Benzazepines: 6-Br-APB Fenoldopam SKF-38,393 SKF-77,434 SKF-81,297 SKF-82,958 SKF-83,959 Trepipam Zelandopam Ergolines: Cabergoline CY-208,243 Dihydroergocryptine LEK-8829 Lisuride Pergolide Terguride Dihydrexidine derivatives: A-77636 A-86929 Adrogolide (ABT-431, DAS-431) Dihydrexidine Dinapsoline Dinoxyline Doxanthrine Phenethylamines: BCO-001 Deoxyepinephrine (N-methyldopamine, epinine) Dopexamine Etilevodopa Ibopamine L-DOPA (levodopa) Melevodopa L-Phenylalanine L-Tyrosine XP21279 Others: A-68930 Apomorphine Isocorypalmine Nuciferine PF-6649751 PF 6669571 Propylnorapomorphine Rotigotine SKF-89,145 SKF-89,626 Stepholidine Tavapadon Tetrahydropalmatine
PAMs	Tetrahydroisoquinolines: DETQ DPTQ Mevidalen
Antagonists	Typical antipsychotics: Butaclamol Chlorpromazine Chlorprothixene Flupentixol (flupenthixol) (+melitracen) Fluphenazine Loxapine Perphenazine (+amitriptyline) Pifluthixol Thioridazine Thiothixene Trifluoperazine (+tranylcypromine) Zuclopenthixol Atypical antipsychotics: Asenapine Clorotepine Clotiapine Clozapine DHA-clozapine Fluperlapine Iloperidone Norclozapine Norquetiapine Olanzapine (+fluoxetine) Paliperidone Quetiapine Risperidone Tefludazine Zicronapine Ziprasidone Zotepine Others: Berupipam Ecopipam EEDQ Metitepine (methiothepin) Odapipam Perlapine SCH-23390

D₂-like

Agonists	Adamantanes: Amantadine Memantine Rimantadine Aminotetralins: 5-OH-DPAT 7-OH-DPAT 8-OH-PBZI Rotigotine UH-232 Ergolines: Bromocriptine Cabergoline Chanoclavine Dihydroergocryptine Epicriptine Ergocornine Lergotrile Lisuride LSD Pergolide Terguride Dihydrexidine derivatives: 2-OH-NPA Ciladopa Dihydrexidine Dinoxyline N,N-Propyldihydrexidine Phenethylamines: Deoxyepinephrine (N-methyldopamine, epinine) Dopexamine Etilevodopa Ibopamine L-DOPA (levodopa) L-Phenylalanine L-Tyrosine Melevodopa XP21279 Atypical antipsychotics: Alentemol (U-66444B) Aripiprazole (+sertraline) Aripiprazole lauroxil Bifeprunox Brexpiprazole Brilaroxazine Cariprazine F-15063 Lumateperone Norclozapine Others: 3-PPP A-412997 ABT-670 ABT-724 Adrafinil Aplindore Apomorphine Arketamine Armodafinil BP-897 Captodiame CP-226,269 Dizocilpine Esketamine Flibanserin Ketamine Mesulergine Modafinil OSU-6162 Pardoprunox PD-128,907 PD-168,077 PF-219,061 PF-592,379 Phencyclidine Piribedil Pramipexole Preclamol Propylnorapomorphine Pukateine Quinagolide Quinelorane Quinpirole RDS-127 Ro10-5824 Ropinirole Roxindole Salvinorin A SKF-83,959 Sumanirole Talipexole Umespirone WAY-100,635
Antagonists	Typical antipsychotics: Acepromazine Acetophenazine Azaperone Benperidol Bromperidol Butaclamol Butaperazine Chloracizine Chlorproethazine Chlorpromazine Chlorprothixene Ciclindole Clopenthixol Clothixamide Clopimozide Droperidol Fluacizine Fluanisone Flucindole Fluotracen Flupentixol (flupenthixol) (+melitracen) Fluphenazine Fluprothixene Fluspirilene Haloperidol Homopipramol Lenperone Levomepromazine (methotrimeprazine) Levosulpiride Loxapine Mesoridazine Moperone Naranol Nemonapride Penfluridol Perathiepin Perazine Pericyazine (periciazine) Perphenazine (+amitriptyline) Piflutixol (pifluthixol) Pimozide Pipamperone Preclamol Prochlorperazine Promazine Prothipendyl Spiperone (spiroperidol) Sulforidazine Sulpiride Sultopride Teflutixol Thiopropazate Thioproperazine Thioridazine Thiothixene Timiperone Trifluoperazine (+tranylcypromine) Triflupromazine Trifluperidol Zetidoline Zuclopenthixol Atypical antipsychotics: Amisulpride Asenapine BL-1020 Blonanserin Carpipramine Cinuperone Clocapramine Clorotepine Clotiapine (clothiapine) Clozapine Cyamemazine DHA-clozapine Dixyrazine Elopiprazole Flumezapine Fluperlapine Gevotroline Iloperidone Lurasidone Mazapertine Melperone Molindone Mosapramine Ocaperidone Olanzapine (+fluoxetine) Paliperidone Perospirone Piperacetazine Pipotiazine Piquindone Quetiapine Remoxipride Risperidone Sertindole Tefludazine Tenilapine Tiospirone Veralipride Zicronapine Ziprasidone Zotepine Antiemetics/gastroprokinetics/sedatives: Aceprometazine AS-8112 Alimemazine Alizapride Benzquinamide Bromopride Clebopride Deudomperidone Domperidone Eticlopride Hydroxyzine Itopride Metoclopramide Metopimazine Promethazine Thiethylperazine Trazpiroben Trimethobenzamide Antidepressants: Amoxapine Nefazodone Opipramol Propiomazine Trimipramine Others: 3-PPP Alpiropride Azapride Bromerguride Bromocriptine Buspirone Desmethoxyfallypride EEDQ F-15063 Fallypride Fananserin Fenfluramine Iodobenzamide Isocorypalmine L-741,626 L-745,870 Levofenfluramine LEK-8829 Metergoline Metitepine (methiothepin) N-Methylspiperone Nafadotride Nuciferine PNU-99,194 Pridopidine Raclopride Sarizotan SB-277,011-A Seridopidine Sonepiprazole Spiroxatrine Stepholidine SV-293 Terguride Tetrahydropalmatine Tiapride UH-232 Yohimbine

Agonists