SWAP70

Protein-coding gene in the species Homo sapiens
SWAP70
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

2DN6

Identifiers
AliasesSWAP70, SWAP-70, HSPC321, SWAP switching B-cell complex 70kDa subunit, SWAP switching B-cell complex subunit 70, switching B-cell complex subunit switching B cell complex subunit SWAP70
External IDsOMIM: 604762; MGI: 1298390; HomoloGene: 7557; GeneCards: SWAP70; OMA:SWAP70 - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for SWAP70
Genomic location for SWAP70
Band11p15.4Start9,664,077 bp[1]
End9,752,993 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for SWAP70
Genomic location for SWAP70
Band7 E3|7 57.7 cMStart109,820,918 bp[2]
End109,882,713 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • Achilles tendon

  • amniotic fluid

  • sural nerve

  • cartilage tissue

  • visceral pleura

  • lower lobe of lung

  • parietal pleura

  • epithelium of nasopharynx

  • palpebral conjunctiva

  • tibia
Top expressed in
  • mesenteric lymph nodes

  • decidua

  • spleen

  • right lung lobe

  • blood

  • left lung lobe

  • stroma of bone marrow

  • calvaria

  • lumbar spinal ganglion

  • femur
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • DNA binding
  • calcium ion binding
  • protein binding
  • ATP binding
  • cadherin binding
Cellular component
  • cell projection
  • membrane
  • plasma membrane
  • cytoskeleton
  • nucleus
  • lamellipodium
  • cytoplasm
Biological process
  • positive regulation of cytosolic calcium ion concentration
  • positive regulation of mast cell chemotaxis
  • negative regulation of peptidyl-serine dephosphorylation
  • negative regulation of actin filament depolymerization
  • actin filament bundle assembly
  • regulation of protein localization
  • regulation of actin polymerization or depolymerization
  • somatic cell DNA recombination
  • isotype switching
  • positive regulation of actin filament bundle assembly
  • negative regulation of cell-cell adhesion mediated by integrin
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

23075

20947

Ensembl

ENSG00000133789

ENSMUSG00000031015

UniProt

Q9UH65

Q6A028

RefSeq (mRNA)

NM_001297714
NM_015055

NM_009302

RefSeq (protein)

NP_001284643
NP_055870

NP_033328

Location (UCSC)Chr 11: 9.66 – 9.75 MbChr 7: 109.82 – 109.88 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Switch-associated protein 70 is a protein that in humans and other mammals is encoded by the SWAP70 gene.[5][6][7][8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000133789 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031015 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
  6. ^ Masat L, Caldwell J, Armstrong R, Khoshnevisan H, Jessberger R, Herndier B, Wabl M, Ferrick D (Apr 2000). "Association of SWAP-70 with the B cell antigen receptor complex". Proc Natl Acad Sci U S A. 97 (5): 2180–4. Bibcode:2000PNAS...97.2180M. doi:10.1073/pnas.040374497. PMC 15774. PMID 10681448.
  7. ^ "Entrez Gene: SWAP70 SWAP-70 protein".
  8. ^ Pearce G, Angeli V, Randolph GJ, Junt T, von Andrian U, Schnittler HJ, Jessberger R (August 2006). "Signaling protein SWAP-70 is required for efficient B cell homing to lymphoid organs". Nat. Immunol. 7 (8): 827–34. doi:10.1038/ni1365. PMID 16845395. S2CID 30891179.

Further reading

  • Borggrefe T, Wabl M, Akhmedov AT, Jessberger R (1998). "A B-cell-specific DNA recombination complex". J. Biol. Chem. 273 (27): 17025–35. doi:10.1074/jbc.273.27.17025. PMID 9642267.
  • Rapalus L, Minegishi Y, Lavoie A, et al. (2002). "Analysis of SWAP-70 as a candidate gene for non-X-linked hyper IgM syndrome and common variable immunodeficiency". Clin. Immunol. 101 (3): 270–5. doi:10.1006/clim.2001.5116. PMID 11726218.
  • Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Hilpelä P, Oberbanscheidt P, Hahne P, et al. (2004). "SWAP-70 identifies a transitional subset of actin filaments in motile cells". Mol. Biol. Cell. 14 (8): 3242–53. doi:10.1091/mbc.E03-01-0043. PMC 181564. PMID 12925760.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Ihara S, Oka T, Fukui Y (2006). "Direct binding of SWAP-70 to non-muscle actin is required for membrane ruffling". J. Cell Sci. 119 (Pt 3): 500–7. doi:10.1242/jcs.02767. PMID 16418221.
  • Kimbara N, Dohi N, Miyamoto M, et al. (2006). "Diagnostic surface expression of SWAP-70 on HIV-1 infected T cells". Microbiol. Immunol. 50 (3): 235–42. doi:10.1111/j.1348-0421.2006.tb03790.x. PMID 16547421. S2CID 85037572.
  • Liu J, Li D, Cao B, et al. (2007). "Expression and localization of SWAP-70 in human fetomaternal interface and placenta during tubal pregnancy and normal placentation". J. Histochem. Cytochem. 55 (7): 701–8. doi:10.1369/jhc.6A7151.2007. PMID 17371938.
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    2dn6: Solution structure of the PH domain of KIAA0640 protein from human


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