USP15

Protein-coding gene in the species Homo sapiens

USP15

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
1W6V, 3LMN, 3PPA, 3PV1, 3T9L, 4A3O, 4A3P, 5JJW

Identifiers

Aliases

USP15, UNPH-2, UNPH4, ubiquitin specific peptidase 15

External IDs

OMIM: 604731; MGI: 101857; HomoloGene: 101542; GeneCards: USP15; OMA:USP15 - orthologs

Gene location (Mouse)

Chr.	Chromosome 10 (mouse)^[1]

Band	10\|10 D2	Start	122,940,911 bp^[1]
Band	10\|10 D2	End	123,032,900 bp^[1]

Gene ontology
Molecular function	ubiquitin modification-dependent histone binding cysteine-type peptidase activity peptidase activity protein binding catalytic activity thiol-dependent deubiquitinase identical protein binding transforming growth factor beta receptor binding cysteine-type endopeptidase activity SMAD binding hydrolase activity
Cellular component	cytoplasm nucleus cytosol mitochondrion
Biological process	pathway-restricted SMAD protein phosphorylation ubiquitin-dependent protein catabolic process monoubiquitinated protein deubiquitination BMP signaling pathway proteolysis histone H2B conserved C-terminal lysine deubiquitination transforming growth factor beta receptor signaling pathway protein deubiquitination
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


9958


14479

Ensembl


ENSG00000135655


ENSMUSG00000020124

UniProt


Q9Y4E8


Q8R5H1

RefSeq (mRNA)


NM_001252078 NM_001252079 NM_006313


NM_001301628 NM_027604

RefSeq (protein)

NP_001239007 NP_001239008 NP_006304 NP_001338088 NP_001338089
NP_001338090 NP_001338091 NP_001338092 NP_001338093 NP_001338094 NP_001338095


NP_001288557 NP_081880

Location (UCSC)

n/a

Chr 10: 122.94 – 123.03 Mb

PubMed search

^[2]

^[3]

Wikidata

View/Edit Human

View/Edit Mouse

Ubiquitin carboxyl-terminal hydrolase 15 is an enzyme that in humans is encoded by the USP15 gene.^[4]^[5]

Ubiquitin is a highly conserved protein involved in the regulation of intracellular protein breakdown, cell cycle regulation, and stress response, which is released from degraded proteins by disassembly of the polyubiquitin chains. The disassembly process is mediated by ubiquitin-specific proteases (USPs).^[5]

References

^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000020124 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Puente XS, Sanchez LM, Overall CM, Lopez-Otin C (Jul 2003). "Human and mouse proteases: a comparative genomic approach". Nat Rev Genet. 4 (7): 544–58. doi:10.1038/nrg1111. PMID 12838346. S2CID 2856065.
^ ^a ^b "Entrez Gene: USP15 ubiquitin specific peptidase 15".

Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
D'Andrea A, Pellman D (1999). "Deubiquitinating enzymes: a new class of biological regulators". Crit. Rev. Biochem. Mol. Biol. 33 (5): 337–52. doi:10.1080/10409239891204251. PMID 9827704.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
de Jong RN, Ab E, Diercks T, et al. (2006). "Solution structure of the human ubiquitin-specific protease 15 DUSP domain". J. Biol. Chem. 281 (8): 5026–31. doi:10.1074/jbc.M510993200. PMID 16298993.
Hetfeld BK, Helfrich A, Kapelari B, et al. (2005). "The zinc finger of the CSN-associated deubiquitinating enzyme USP15 is essential to rescue the E3 ligase Rbx1". Curr. Biol. 15 (13): 1217–21. doi:10.1016/j.cub.2005.05.059. PMID 16005295. S2CID 15396259.
Soboleva TA, Jans DA, Johnson-Saliba M, Baker RT (2005). "Nuclear-cytoplasmic shuttling of the oncogenic mouse UNP/USP4 deubiquitylating enzyme". J. Biol. Chem. 280 (1): 745–52. doi:10.1074/jbc.M401394200. PMID 15494318.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Angelats C, Wang XW, Jermiin LS, et al. (2003). "Isolation and characterization of the mouse ubiquitin-specific protease Usp15". Mamm. Genome. 14 (1): 31–46. doi:10.1007/s00335-002-3035-0. PMID 12532266. S2CID 23215004.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Baker RT, Wang XW, Woollatt E, et al. (1999). "Identification, functional characterization, and chromosomal localization of USP15, a novel human ubiquitin-specific protease related to the UNP oncoprotein, and a systematic nomenclature for human ubiquitin-specific proteases". Genomics. 59 (3): 264–74. doi:10.1006/geno.1999.5879. PMID 10444327.
Nagase T, Ishikawa K, Miyajima N, et al. (1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (1): 31–9. doi:10.1093/dnares/5.1.31. PMID 9628581.