NOD2 |
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Structures disponibles |
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PDB | Recherche d'orthologue: PDBe RCSB |
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Identifiants PDB |
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5IRL, 5IRM, 5IRN |
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Identifiants |
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Aliases | NOD2 |
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IDs externes | OMIM: 605956 MGI: 2429397 HomoloGene: 11156 GeneCards: NOD2 |
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Position du gène (Homme) |
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| Chr. | Chromosome 16 humain[1] |
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| Locus | 16q12.1 | Début | 50,693,588 bp[1] |
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Fin | 50,734,041 bp[1] |
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Position du gène (Souris) |
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| Chr. | Chromosome 8 (souris)[2] |
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| Locus | 8|8 C3 | Début | 89,373,943 bp[2] |
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Fin | 89,415,102 bp[2] |
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Expression génétique |
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Bgee | Humain | Souris (orthologue) |
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Fortement exprimé dans | - monocyte
- granulocyte
- sang
- skin of leg
- skin of abdomen
- vulve
- pénis humain
- cartilage tissue
- cellule de la moelle osseuse
- vagin
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| Fortement exprimé dans | - granulocyte
- secondary oocyte
- primary oocyte
- zygote
- embryon
- œsophage
- zone of skin
- lèvre
- muscle quadriceps fémoral
- duodénum
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| Plus de données d'expression de référence |
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BioGPS | | Plus de données d'expression de référence |
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Gene Ontology |
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Fonction moléculaire | - Hsp90 protein binding
- liaison nucléotide
- Hsp70 protein binding
- liaison protéique
- peptidoglycan binding
- liaison enzymatique
- actin binding
- CARD domain binding
- liaison ATP
- protein kinase binding
- muramyl dipeptide binding
- liaison de complexe macromoléculaire
| Composant cellulaire | - cytoplasme
- cytosol
- vésicule
- membrane
- membrane plasmique
- surface cellulaire
- basolateral plasma membrane
- COP9 signalosome
- cytosquelette
- appareil de Golgi
- mitochondrie
- complexe macromoléculaire
| Processus biologique | - positive regulation of prostaglandin-endoperoxide synthase activity
- regulation of apoptotic process
- réponse de défense
- detection of biotic stimulus
- cytokine production involved in immune response
- positive regulation of cytokine production involved in inflammatory response
- intracellular signal transduction
- detection of muramyl dipeptide
- positive regulation of interleukin-10 production
- positive regulation of epithelial cell proliferation
- processus du système immunitaire
- positive regulation of oxidoreductase activity
- response to muramyl dipeptide
- positive regulation of prostaglandin-E synthase activity
- positive regulation of JNK cascade
- positive regulation of nitric-oxide synthase biosynthetic process
- positive regulation of NIK/NF-kappaB signaling
- positive regulation of phosphatidylinositol 3-kinase activity
- positive regulation of gamma-delta T cell activation
- cellular response to muramyl dipeptide
- JNK cascade
- negative regulation of macrophage apoptotic process
- positive regulation of dendritic cell antigen processing and presentation
- nucleotide-binding oligomerization domain containing 2 signaling pathway
- maintenance of gastrointestinal epithelium
- defense response to bacterium
- positive regulation of NF-kappaB transcription factor activity
- positive regulation of interleukin-8 production
- detection of bacterium
- positive regulation of interleukin-1 beta production
- regulation of inflammatory response
- positive regulation of interleukin-6 production
- protein complex oligomerization
- positive regulation of tumor necrosis factor production
- positive regulation of ERK1 and ERK2 cascade
- positive regulation of I-kappaB kinase/NF-kappaB signaling
- positive regulation of B cell activation
- positive regulation of interleukin-17 production
- positive regulation of type 2 immune response
- nucleotide-binding oligomerization domain containing signaling pathway
- positive regulation of stress-activated MAPK cascade
- positive regulation of Notch signaling pathway
- positive regulation of transcription by RNA polymerase II
- cellular response to organic cyclic compound
- positive regulation of cell population proliferation
- système immunitaire inné
- response to nutrient
- positive regulation of dendritic cell cytokine production
- positive regulation of protein K63-linked ubiquitination
- cellular response to peptidoglycan
- positive regulation of MAP kinase activity
- interleukin-1-mediated signaling pathway
- cellular response to lipopolysaccharide
| Sources:Amigo / QuickGO |
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Orthologues |
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Espèces | Homme | Souris |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | |
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NM_001293557 NM_022162 NM_001370466 |
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RefSeq (protéine) | |
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NP_001280486 NP_071445 NP_001357395 |
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Localisation (UCSC) | Chr 16: 50.69 – 50.73 Mb | Chr 8: 89.37 – 89.42 Mb |
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Publication PubMed | [3] | [4] |
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Wikidata |
Voir/Editer Humain | Voir/Editer Souris |
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NOD2 (« nucleotide-binding oligomerization domain 2 »), appelé également CARD15 (« caspase recruitment domain-containing protein 15 ») est une protéine constituant l'un des deux types de récepteur NOD. Son gène est le NOD2 situé sur le chromosome 16 humain.
Rôles
Avec le NOD1, il contribue à la détection des bactéries intra cellulaire et à leur destruction[5]. Il reconnait ainsi le muramyldipeptide, un peptidoglycane bactérien[6].
NOD2 active la voie de la prostaglandine E2 et pourrait intervenir, par ce biais, dans la genèse de l'athérome[7].
Il est exprimé également dans le plaquettes sanguines avec un rôle dans la formation des thromboses[8].
En médecine
Certaines mutations de son gène augmentent le risque de développer une maladie de Crohn[9].
Notes et références
- ↑ a b et c GRCh38: Ensembl release 89: ENSG00000167207 - Ensembl, May 2017
- ↑ a b et c GRCm38: Ensembl release 89: ENSMUSG00000055994 - Ensembl, May 2017
- ↑ « Publications PubMed pour l'Homme », sur National Center for Biotechnology Information, U.S. National Library of Medicine
- ↑ « Publications PubMed pour la Souris », sur National Center for Biotechnology Information, U.S. National Library of Medicine
- ↑ Philpott DJ, Sorbara MT, Robertson SJ, Croitoru K, Girardin SE, NOD proteins: regulators of inflammation in health and disease, Nat Rev Immunol, 2014;14:9–23
- ↑ Girardin SE, Boneca IG, Viala J, Chamaillard M, Labigne A, Thomas G, Philpott DJ, Sansonetti PJ, Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection, J Biol Chem, 2003;278:8869–8872
- ↑ Liu HQ, Zhang XY, Edfeldt K et al. NOD2-mediated innate immune signaling regulates the eicosanoids in atherosclerosis, Arterioscler Thromb Vasc Biol, 2013;33:2193–2201
- ↑ Zhang S, Zhang S, Hu L et al. Nucleotide-binding Oligomerization Domain 2 receptor is expressed in platelets and enhances platelet activation and thrombosis, Circulation, 2015;131:1160-1170
- ↑ Ogura Y, Bonen DK, Inohara N et al. A frameshift mutation in NOD2 associated with susceptibility to Crohn’s disease, Nature, 2001;411:603–606
- Portail de la médecine
- Portail de la biologie cellulaire et moléculaire