| År | Singel | UK Singles Chart | U.S. Billboard Hot 100 | U.S. Mainstream Rock | U.S. Modern Rock | Album |
| 1981 | "Radio Free Europe" (Hib-Tone version) | – | – | – | – | Utgitt før første album |
| 1983 | "Radio Free Europe" (nyinnspilt versjon) | – | 78 | 25 | – | Murmur |
| "Talk About the Passion" | – | – | – | – |
| 1984 | "So. Central Rain (I'm Sorry)" | – | 85 | – | – | Reckoning |
| "(Don't Go Back to) Rockville" | – | – | – | – |
| 1985 | "Cant Get There From Here" | – | – | 14 | – | Fables of the Reconstruction |
| "Driver 8" | – | – | 22 | – |
| "Wendell Gee" | 91 | – | – | – |
| 1986 | "Fall On Me" | – | 94 | 5 | – | Lifes Rich Pageant |
| "Superman" | – | – | 17 | – |
| 1987 | "Ages of You" | – | – | 39 | – | Dead Letter Office |
| "The One I Love" | 16 | 9 | 2 | – | Document |
| "It’s the End of the World as We Know It (And I Feel Fine)" | 39 | 69 | 16 | – |
| 1988 | "Finest Worksong" | 50 | – | 28 | – |
| "Stand" | 48 | 6 | 1 | 1(2) | Green |
| "Orange Crush" | 28 | – | 1 | 1(8) |
| 1989 | "Pop Song 89" | – | 86 | 14 | 16 |
| "Get Up" | – | – | – | – |
| "Turn You Inside-Out" | – | – | 7 | 10 |
| 1991 | "Losing My Religion" | 19 | 4 | 1 | 1(8) | Out of Time |
| "Shiny Happy People" | 6 | 10 | 8 | 3 |
| "Near Wild Heaven" | 27 | – | – | – |
| "Radio Song" | 28 | – | – | – |
| "Texarkana" | – | – | 7 | 4 |
| 1992 | "Drive" | 11 | 28 | 2 | 1(5) | Automatic for the People |
| "First We Take Manhattan" | – | – | – | 11 | I'm Your Fan: The Songs Of Leonard Cohen |
| "Ignoreland" | – | – | 4 | 5 | Automatic for the People |
| 1993 | "Man on the Moon" | 18 | 30 | 4 | 2(1) |
| "The Sidewinder Sleeps Tonite" | 17 | – | 28 | 24 |
| "Everybody Hurts" | 7 | 29 | – | 21 |
| "Nightswimming" | 28 | – | – | – |
| "Find the River" | 54 | – | – | – |
| "Photograph" | – | – | – | 9 | Born To Choose |
| 1994 | "What's the Frequency, Kenneth?" | 9 | 21 | 2 | 1(5) | Monster |
| "Bang and Blame" | 15 | 19 | 3 | 1(3) |
| 1995 | "Star 69" | – | – | 15 | 8 |
| "Strange Currencies" | 9 | 47 | 8 | 14 |
| "Crush With Eyeliner" (Kun utgitt i UK) | 23 | – | 20 | 33 |
| "Tongue" (Kun utgitt i UK) | 13 | – | – | – |
| 1996 | "E-Bow the Letter" | 4 | 49 | 15 | 2(1) | New Adventures In Hi-Fi |
| "Bittersweet Me" | 19 | 46 | 7 | 6 |
| 1997 | "Electrolite" | 29 | 96 | – | – |
| "How the West Was Won and Where It Got Us" | – | – | – | – |
| "The Wake-Up Bomb" | – | – | 30 | – |
| 1998 | "Daysleeper" | 6 | 57 | 30 | 18 | Up |
| "Lotus" | 26 | – | 31 | 31 |
| 1999 | "At My Most Beautiful" | 10 | – | – | – |
| "Suspicion" | – | – | – | – |
| 2000 | "The Great Beyond" | 3 | 57 | 33 | 11 | Man on the Moon OST |
| 2001 | "Imitation of Life" | 6 | 83 | – | 22 | Reveal |
| "All the Way to Reno (You're Gonna Be a Star)" | 24 | – | – | – |
| "I'll Take the Rain" | 44 | – | – | – |
| 2003 | "Bad Day" | 8 | – | – | – | In Time: The Best of R.E.M. |
| 2004 | "Animal" | 33 | – | – | – |
| "Leaving New York" | 5 | – | – | – | Around the Sun |
| "Aftermath" | 41 | – | – | – |
| 2005 | "Electron Blue" | 26 | – | – | – |
| "Wanderlust" | 27 | – | – | – |
| 2007 | "#9 Dream" | – | 101 | – | – | Instant Karma: The Amnesty International Campaign to Save Darfur |
