Čargafova pravila

Čargafova pravila tvrde da DNK iz bilo koje ćelije i bilo kog organizma treba da ima 1:1 odnos (pravilo baznih parova) pirimidinskih i purinskih baza, i specifičnije, da je količina guanina jednaka količini citozina, a količina adenina je jednaka količini timina. Ovaj obraz je nađen u oba lanca DNK. Ova pravila je otkrio austrijski hemičar Ervin Čargaf.[1][2][3][4][5][6]

Reference

  1. ↑ Elson D, Chargaff E (1952). „On the deoxyribonucleic acid content of sea urchin gametes”. Experientia 8 (4): 143–145. DOI:10.1007/BF02170221. PMID 14945441. 
  2. ↑ Chargaff E, Lipshitz R, Green C (1952). „Composition of the deoxypentose nucleic acids of four genera of sea-urchin”. J Biol Chem 195 (1): 155–160. PMID 14938364. 
  3. ↑ Chargaff E, Lipshitz R, Green C, Hodes ME (1951). „The composition of the deoxyribonucleic acid of salmon sperm”. J Biol Chem 192 (1): 223–230. PMID 14917668. 
  4. ↑ Chargaff E (1951). „Some recent studies on the composition and structure of nucleic acids”. J Cell Physiol Suppl 38 (Suppl). 
  5. ↑ Magasanik B, Vischer E, Doniger R, Elson D, Chargaff E (1950). „The separation and estimation of ribonucleotides in minute quantities”. J Biol Chem 186 (1): 37–50. PMID 14778802. 
  6. ↑ Chargaff E (1950). „Chemical specificity of nucleic acids and mechanism of their enzymatic degradation”. Experientia 6 (6): 201–209. DOI:10.1007/BF02173653. PMID 15421335. 

Literatura

  • Szybalski W, Kubinski H, Sheldrick P (1966). „Pyrimidine clusters on the transcribing strands of DNA and their possible role in the initiation of RNA synthesis”. Cold Spring Harbor NY Symp. Quant Biol 31: 123–127. DOI:10.1101/SQB.1966.031.01.019. PMID 4966069. 
  • Lobry JR (1996). „Asymmetric substitution patterns in the two DNA strands of bacteria”. Mol. Biol. Evol. 13 (5): 660–665. DOI:10.1093/oxfordjournals.molbev.a025626. PMID 8676740. 
  • Lafay B, Lloyd AT, McLean MJ, Devine KM, Sharp PM, Wolfe KH (1999). „Proteome composition and codon usage in spirochaetes: species-specific and DNA strand-specific mutational biases”. Nucleic Acids Res 27 (7): 1642–1649. DOI:10.1093/nar/27.7.1642. PMC 148367. PMID 10075995. 
  • McLean MJ, Wolfe KH, Devine KM (1998). „Base composition skews, replication orientation, and gene orientation in 12 prokaryote genomes”. J Mol Evol 47 (6): 691–696. DOI:10.1007/PL00006428. PMID 9847411. 
  • McInerney JO (1998). „Replicational and transcriptional selection on codon usage in Borrelia burgdorferi”. Proc Natl Acad Sci USA 95 (18): 10698–10703. DOI:10.1073/pnas.95.18.10698. PMC 27958. PMID 9724767.