Ajulemska kiselina

Ajulemska kiselina
(IUPAC) ime
(6aR,10aR)-3-(1,1-dimetilheptil)-6a,7,10,10a-tetrahidro-1-hidroksi-6,6-dimetil-6H-Dibenzo(b,d)piran-9-karboksilna kiselina
Klinički podaci
Identifikatori
CAS broj 137945-48-3
ATC kod nije dodeljen
PubChem[1][2] 3083542
ChemSpider[3] 21106251
ChEMBL[4] CHEMBL456341 DaY
Hemijski podaci
Formula C25H36O4 
Mol. masa 400,551 g/mol
SMILES eMolekuli & PubHem
InChI
InChI=1S/C25H36O4/c1-6-7-8-9-12-24(2,3)17-14-20(26)22-18-13-16(23(27)28)10-11-19(18)25(4,5)29-21(22)15-17/h10-11,14-16,18-19,26H,6-9,12-13H2,1-5H3,(H,27,28)/t16?,18-,19-/m1/s1 DaY
Key: QHGPTMABBHVVQU-VOBHOPKGSA-N DaY
Farmakoinformacioni podaci
Trudnoća ?
Pravni status

Ajulemska kiselina (AB-III-56, HU-239, IP-751) je sintetički kanabinoidni derivat psiho-neaktivnog THC metabolita 11-nor-9-karboksi-THC. Ovo jedinjenje deluje kao analgetik i antiinflamatorni agens.[5] Ajulemska kiselina je razvijena za tretman neuropatičkog bola i inflamatornih oboljenja poput artritisa.[6]

Reference

  1. ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1. 
  3. ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.  edit
  4. ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.  edit
  5. ↑ Burstein, S.; Karst, M.; Schneider, U.; Zurier, R. (2004). „Ajulemic acid: A novel cannabinoid produces analgesia without a "high"”. Life Sciences 75 (12): 1513–1522. DOI:10.1016/j.lfs.2004.04.010. PMID 15240185. 
  6. ↑ Mitchell, V.; Aslan, S.; Safaei, R.; Vaughan, C. (2005). „Effect of the cannabinoid ajulemic acid on rat models of neuropathic and inflammatory pain”. Neuroscience letters 382 (3): 231–235. DOI:10.1016/j.neulet.2005.03.019. PMID 15925096. 

Šablon:Kanabinoidi