Droperidol
(IUPAC) ime | |||
---|---|---|---|
1-{1-[4-(4-fluorofenil)-4-oksobutil]-1,2,5,6-tetrahidropiridin-4-il}-1,3-dihidro-2H-benzimidazol-2-on | |||
Klinički podaci | |||
Identifikatori | |||
CAS broj | 548-73-2 | ||
ATC kod | N05AD08 | ||
PubChem[1][2] | 3168 | ||
DrugBank | DB00450 | ||
UNII | O9U0F09D5X Y | ||
KEGG[3] | D00308 | ||
ChEMBL[4] | CHEMBL1108 Y | ||
Hemijski podaci | |||
Formula | C22H22FN3O2 | ||
Mol. masa | 379,428 g/mol | ||
SMILES | eMolekuli & PubHem | ||
| |||
Farmakokinetički podaci | |||
Metabolizam | Hepatički | ||
Poluvreme eliminacije | 2,3 sata | ||
Farmakoinformacioni podaci | |||
Trudnoća | ? | ||
Pravni status | ℞-only (SAD) | ||
Način primene | Intravenozno, Intramaskularno |
Droperidol (Inapsine, Droleptan, Dridol, Xomolix, Innovar [kombinacija sa fentanilom]) je antidopaminergički lek koji se koristi kao antiemetik i antipsihotik.[5][6] Droperidol se takođe koristi za neuroleptanalgezijsku anesteziju i sedaciju pri intenzivnoj nezi.
Hemija
Droperidol se može sintetisati iz 1-benzil-3-karbetoksipiperidin-4-ona, reakcijom sa o-fenilendiaminom.[7][8][9][10]
Reference
- ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
- ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
- ↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H.
- ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594. edit
- ↑ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035-41. PMID 21059682.
- ↑ Wishart DS, Knox C, Guo AC, Cheng D, Shrivastava S, Tzur D, Gautam B, Hassanali M (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Res 36 (Database issue): D901-6. PMID 18048412.
- ↑ C. Janssen, NV Res. Lab., GB 989755 (1962).
- ↑ Janssen, P. A. J.; 1963, Belgian Patent BE 626307 .
- ↑ F.J. Gardocki, J. Janssen, U.S. Patent 3.141.823 (1964).
- ↑ P.A.J. Janssen, U.S. Patent 3.161.645 (1964).
Literatura
- Scuderi PE: Droperidol: Many questions, few answers. Anesthesiology 2003; 98: 289-90
- Lischke V, Behne M, Doelken P, Schledt U, Probst S, Vettermann J. Droperidol causes a dose-dependent prolongation of the QT interval. Department of Anesthesiology and Resuscitation, Johann Wolfgang Goethe-University Clinics, Frankfurt am Main, Germany.
- Emergency Medicine Magazine : http://www.emedmag.com/html/pre/tri/1005.asp Arhivirano 2011-05-27 na Wayback Machine-u
Spoljašnje veze
Portal Medicina | |
Portal Hemija |
- p
- r
- u
Butirofenoni: Azaperon • Benperidol • Bromperidol • Droperidol • Fluanizon • Haloperidol # • Lenperon • Moperon • Pipamperon • Spiperon • Timiperon • Trifluperidol
Difenilbutilpiperidini: Klopimozid • Fluspirilen • Penfluridol • Pimozid
Fenotiazini: Acepromazin • Acetofenazin • Butaperazin • Karfenazin • Hloracizin • Hlorproetazin • Hlorpromazin • Cijamemazin • Diksirazin • Fluacizin • Flufenazin • Levomepromazin/Metotrimeprazin • Mezoridazin • Perazin • Pericijazin • Perfenazin • Piperacetazin • Pipotiazin • Prohlorperazin • Promazin • Prometazin • Propiomazin • Sulforidazin • Tietilperazin • Tiopropazat • Tioproperazin • Tioridazin • Trifluoperazin • Triflupromazin
Tioksanten: Hlorprotiksen • Klopentiksol • Flupentiksol • Tiotiksen • Zuklopentiksol
Triciklici: Butaklamol • Fluotracen • Loksapin • Trimipramin
Drugi: ProtipendilButirofenoni: Cinuperon • Melperon • Setoperon
Benzo(izo)oksazolpiperidini: Iloperidon • Okaperidon • Paliperidon • Risperidon #
Benzo(izo)tiazolpiperazini: Lurasidone • Perospiron • Revospiron • Tiospiron • Ziprasidon
Difenilbutilpiperazini: Amperozid
Fenilpiperazini: Aripiprazol • Bifeprunoks • Brekspiprazol† • Elopiprazol • Umespiron
Triciklici: Amoksapin • Asenapin • Karpipramin • Klocapramin • Klorotepin • Klotiapin • Klozapin # • Fluperlapin • Gevotrolin • Metitepin • Mosapramin • NDMC • Olanzapin • Pihindon • Kvetijapin • Tenilapin • Zotepin
Drugi: Blonanserin • Kariprazin • Molindon • Pimavanserin • Roksindol • Sarizotan • Sertindol • Spiramid • Zikronapin†#WHO-EM • ‡Povučeni sa tržišta • Klinička ispitivanja: †Faza III • §Nije dospeo do faze III