Keratin 17

Protein-coding gene in the species Homo sapiens
KRT17
Identifiers
AliasesKRT17, K17, PC, PC2, PCHC1, 39.1, CK-17, keratin 17
External IDsOMIM: 148069; MGI: 96691; HomoloGene: 363; GeneCards: KRT17; OMA:KRT17 - orthologs
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for KRT17
Genomic location for KRT17
Band17q21.2Start41,619,442 bp[1]
End41,624,842 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for KRT17
Genomic location for KRT17
Band11 D|11 63.44 cMStart100,147,043 bp[2]
End100,151,855 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • amniotic fluid

  • vulva

  • hair follicle

  • skin of abdomen

  • nipple

  • body of tongue

  • minor salivary glands

  • lactiferous duct

  • trachea

  • periodontal fiber
Top expressed in
  • lip

  • molar

  • skin of back

  • epidermis

  • hair follicle

  • skin of abdomen

  • thymus

  • corneal stroma

  • conjunctival fornix

  • cervix
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • structural constituent of cytoskeleton
  • MHC class II receptor activity
  • protein binding
  • structural molecule activity
  • MHC class II protein binding
Cellular component
  • cytoplasm
  • extracellular exosome
  • intermediate filament
  • cell periphery
  • cytosol
  • intermediate filament cytoskeleton
Biological process
  • morphogenesis of an epithelium
  • positive regulation of hair follicle development
  • hair follicle morphogenesis
  • intermediate filament organization
  • positive regulation of cell growth
  • positive regulation of translation
  • signal transduction
  • epidermis development
  • keratinization
  • cornification
  • cytoskeleton organization
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

3872

16667

Ensembl

ENSG00000128422

ENSMUSG00000035557

UniProt

Q04695

Q9QWL7

RefSeq (mRNA)

NM_000422

NM_010663

RefSeq (protein)

NP_000413

NP_034793

Location (UCSC)Chr 17: 41.62 – 41.62 MbChr 11: 100.15 – 100.15 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Keratin, type I cytoskeletal 17 is a protein that in humans is encoded by the KRT17 gene.[5][6][7][8]

Keratin 17 is a type I cytokeratin. It is found in nail beds, hair follicles, sebaceous glands, and other epidermal appendages. Mutations in the gene encoding this protein lead to PC-K17 (previously known as Jackson-Lawler) type pachyonychia congenita and steatocystoma multiplex.[8]

Interactions

Keratin 17 has been shown to interact with CCDC85B.[9]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000128422 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035557 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ McLean WH, Rugg EL, Lunny DP, Morley SM, Lane EB, Swensson O, Dopping-Hepenstal PJ, Griffiths WA, Eady RA, Higgins C (Jul 1995). "Keratin 16 and keratin 17 mutations cause pachyonychia congenita". Nat Genet. 9 (3): 273–8. doi:10.1038/ng0395-273. PMID 7539673. S2CID 1873772.
  6. ^ Troyanovsky SM, Leube RE, Franke WW (Jan 1993). "Characterization of the human gene encoding cytokeratin 17 and its expression pattern". Eur J Cell Biol. 59 (1): 127–37. PMID 1281771.
  7. ^ Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (Jul 2006). "New consensus nomenclature for mammalian keratins". J Cell Biol. 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC 2064177. PMID 16831889.
  8. ^ a b "Entrez Gene: KRT17 keratin 17".
  9. ^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

Further reading

  • Flohr T, Buwitt U, Bonnekoh B, Decker T, Böttger EC (1992). "Interferon-gamma regulates expression of a novel keratin class I gene". Eur. J. Immunol. 22 (4): 975–9. doi:10.1002/eji.1830220415. PMID 1372562. S2CID 85892865.
  • Trask DK, Band V, Zajchowski DA, Yaswen P, Suh T, Sager R (1990). "Keratins as markers that distinguish normal and tumor-derived mammary epithelial cells". Proc. Natl. Acad. Sci. U.S.A. 87 (6): 2319–23. Bibcode:1990PNAS...87.2319T. doi:10.1073/pnas.87.6.2319. PMC 53678. PMID 1690428.
  • Kartasova T, Cornelissen BJ, Belt P, van de Putte P (1987). "Effects of UV, 4-NQO and TPA on gene expression in cultured human epidermal keratinocytes". Nucleic Acids Res. 15 (15): 5945–62. doi:10.1093/nar/15.15.5945. PMC 306060. PMID 2442723.
  • Takahashi K, Folmer J, Coulombe PA (1994). "Increased expression of keratin 16 causes anomalies in cytoarchitecture and keratinization in transgenic mouse skin". J. Cell Biol. 127 (2): 505–20. doi:10.1083/jcb.127.2.505. PMC 2120213. PMID 7523421.
  • Munro CS, Carter S, Bryce S, Hall M, Rees JL, Kunkeler L, Stephenson A, Strachan T (1995). "A gene for pachyonychia congenita is closely linked to the keratin gene cluster on 17q12-q21". J. Med. Genet. 31 (9): 675–8. doi:10.1136/jmg.31.9.675. PMC 1050075. PMID 7529318.
  • Leigh IM, Navsaria H, Purkis PE, McKay IA, Bowden PE, Riddle PN (1995). "Keratins (K16 and K17) as markers of keratinocyte hyperproliferation in psoriasis in vivo and in vitro". Br. J. Dermatol. 133 (4): 501–11. doi:10.1111/j.1365-2133.1995.tb02696.x. PMID 7577575. S2CID 85097321.
  • Smith FJ, Corden LD, Rugg EL, Ratnavel R, Leigh IM, Moss C, Tidman MJ, Hohl D, Huber M, Kunkeler L, Munro CS, Lane EB, McLean WH (1997). "Missense mutations in keratin 17 cause either pachyonychia congenita type 2 or a phenotype resembling steatocystoma multiplex". J. Invest. Dermatol. 108 (2): 220–3. doi:10.1111/1523-1747.ep12335315. PMID 9008238.
  • Covello SP, Smith FJ, Sillevis Smitt JH, Paller AS, Munro CS, Jonkman MF, Uitto J, McLean WH (1999). "Keratin 17 mutations cause either steatocystoma multiplex or pachyonychia congenita type 2". Br. J. Dermatol. 139 (3): 475–80. doi:10.1046/j.1365-2133.1998.02413.x. PMID 9767294. S2CID 22421872.
  • McGowan KM, Coulombe PA (1998). "Onset of keratin 17 expression coincides with the definition of major epithelial lineages during skin development". J. Cell Biol. 143 (2): 469–86. doi:10.1083/jcb.143.2.469. PMC 2132846. PMID 9786956.
  • Schön M, Benwood J, O'Connell-Willstaedt T, Rheinwald JG (1999). "Human sweat gland myoepithelial cells express a unique set of cytokeratins and reveal the potential for alternative epithelial and mesenchymal differentiation states in culture". J. Cell Sci. 112 (12): 1925–36. doi:10.1242/jcs.112.12.1925. PMID 10341211.
  • Celebi JT, Tanzi EL, Yao YJ, Michael EJ, Peacocke M (1999). "Mutation report: identification of a germline mutation in keratin 17 in a family with pachyonychia congenita type 2". J. Invest. Dermatol. 113 (5): 848–50. doi:10.1046/j.1523-1747.1999.00762.x. PMID 10571744.
  • Smith FJ, Coleman CM, Bayoumy NM, Tenconi R, Nelson J, David A, McLean WH (2001). "Novel keratin 17 mutations in pachyonychia congenita type 2". J. Invest. Dermatol. 116 (5): 806–8. doi:10.1046/j.0022-202x.2001.doc.x. PMID 11348474.
  • Suzuki H, Fukunishi Y, Kagawa I, Saito R, Oda H, Endo T, Kondo S, Bono H, Okazaki Y, Hayashizaki Y (2001). "Protein-protein interaction panel using mouse full-length cDNAs". Genome Res. 11 (10): 1758–65. doi:10.1101/gr.180101. PMC 311163. PMID 11591653.
  • Hashiguchi T, Yotsumoto S, Shimada H, Terasaki K, Setoyama M, Kobayashi K, Saheki T, Kanzaki T (2002). "A novel point mutation in the keratin 17 gene in a Japanese case of pachyonychia congenita type 2". J. Invest. Dermatol. 118 (3): 545–7. doi:10.1046/j.0022-202x.2001.01701.x. PMID 11874497.
  • Terrinoni A, Smith FJ, Didona B, Canzona F, Paradisi M, Huber M, Hohl D, David A, Verloes A, Leigh IM, Munro CS, Melino G, McLean WH (2002). "Novel and recurrent mutations in the genes encoding keratins K6a, K16 and K17 in 13 cases of pachyonychia congenita". J. Invest. Dermatol. 117 (6): 1391–6. doi:10.1046/j.0022-202x.2001.01565.x. PMID 11886499.
  • Scherl A, Couté Y, Déon C, Callé A, Kindbeiter K, Sanchez JC, Greco A, Hochstrasser D, Diaz JJ (2003). "Functional proteomic analysis of human nucleolus". Mol. Biol. Cell. 13 (11): 4100–9. doi:10.1091/mbc.E02-05-0271. PMC 133617. PMID 12429849.
  • van de Rijn M, Perou CM, Tibshirani R, Haas P, Kallioniemi O, Kononen J, Torhorst J, Sauter G, Zuber M, Köchli OR, Mross F, Dieterich H, Seitz R, Ross D, Botstein D, Brown P (2003). "Expression of cytokeratins 17 and 5 identifies a group of breast carcinomas with poor clinical outcome". Am. J. Pathol. 161 (6): 1991–6. doi:10.1016/S0002-9440(10)64476-8. PMC 1850928. PMID 12466114.

External links

  • GeneReviews/NCBI/NIH/UW entry on Pachyonychia Congenita
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Human
Microfilaments
and ABPs
Myofilament
Actins
Myosins
Other
Other
Intermediate
filaments
Type 1/2
(Keratin,
Cytokeratin)
Epithelial keratins
(soft alpha-keratins)
Hair keratins
(hard alpha-keratins)
Ungrouped alpha
Not alpha
Type 3
Type 4
Type 5
Microtubules
and MAPs
Tubulins
MAPs
Kinesins
Dyneins
Microtubule organising proteins
Microtubule severing proteins
Other
Catenins
Membrane
Other
Nonhuman
See also: cytoskeletal defects


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