Aminofilin

Aminofilin
(IUPAC) ime
1,3-dimetil-7H-purin-2,6-dion; ethan-1,2-diamin
Klinički podaci
AHFS/Drugs.com Potrošačka informacije o leku
MedlinePlus a601015
Identifikatori
CAS broj 317-34-0
ATC kod R03DA05
PubChem[1][2] 9433
DrugBank DB01223
ChemSpider[3] 9062
UNII 27Y3KJK423 DaY
KEGG[4] D00227 DaY
ChEMBL[5] CHEMBL1210 DaY
Hemijski podaci
Formula C16H24N10O4 
Mol. masa 420,427 g/mol
SMILES eMolekuli & PubHem
InChI
InChI=1S/2C7H8N4O2.C2H8N2/c2*1-10-5-4(8-3-9-5)6(12)11(2)7(10)13;3-1-2-4/h2*3H,1-2H3,(H,8,9);1-4H2 DaY
Key: FQPFAHBPWDRTLU-UHFFFAOYSA-N DaY
Farmakokinetički podaci
Vezivanje za proteine plazme 60%
Poluvreme eliminacije 7-9 sata
Farmakoinformacioni podaci
Trudnoća ?
Pravni status P (UK)
Način primene oralno, i.v.

Aminofilin je bronhodilatator. On se sastoji od teofilina sa etilendiaminom u odnosu 2:1. Etilendiamin poboljšava rastvorljivost. Aminofilin se obično nalazi kao dihidrat[6] Aminofilin je neselektivan antagonist adenozinskog receptora i inhibitor fosfodiesteraze.[7][7][8]

Reference

  1. ↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519.  edit
  2. ↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1. 
  3. ↑ Hettne KM, Williams AJ, van Mulligen EM, Kleinjans J, Tkachenko V, Kors JA. (2010). „Automatic vs. manual curation of a multi-source chemical dictionary: the impact on text mining”. J Cheminform 2 (1): 3. DOI:10.1186/1758-2946-2-3. PMID 20331846.  edit
  4. ↑ Joanne Wixon, Douglas Kell (2000). „Website Review: The Kyoto Encyclopedia of Genes and Genomes — KEGG”. Yeast 17 (1): 48–55. DOI:10.1002/(SICI)1097-0061(200004)17:1<48::AID-YEA2>3.0.CO;2-H. 
  5. ↑ Gaulton A, Bellis LJ, Bento AP, Chambers J, Davies M, Hersey A, Light Y, McGlinchey S, Michalovich D, Al-Lazikani B, Overington JP. (2012). „ChEMBL: a large-scale bioactivity database for drug discovery”. Nucleic Acids Res 40 (Database issue): D1100-7. DOI:10.1093/nar/gkr777. PMID 21948594.  edit
  6. ↑ „Aminophylline Professional Monograph”. 
  7. ↑ 7,0 7,1 Mader, TJ; Smithline HA, Durkin L, Scriver G (March 2003). „A randomized control trial of intravenous aminophylline for atropine-resistant out-of-hospital asystolic cardiac arrest”. Academic Emergency Medical Journal 10 (3): 192–197. Arhivirano iz originala na datum 2017-06-10. Pristupljeno 2012-02-10. 
  8. ↑ Mader, TJ; Gibson, P (January 1997). cws_home/505959/description#description „Adenosine receptor antagonism in refractory asystolic cardiac arrest: results of a human pilot study”. Elsevier Resuscitation 35: 3–7. Pristupljeno 2012-02-10. 
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Receptorski ligandi
2-(1-Heksinil)-N-metiladenozin • 2-Cl-IB-MECA • 2'-MeCCPA • 5'-N-etilkarboksamidoadenozin • ATL-146e • BAY 60-6583 • CCPA • CGS-21680 • CP-532,903 • GR 79236 • LUF-5835 • LUF-5845 • N6-Ciklopentiladenozin • Regadenoson • SDZ WAG 994 • UK-432,097
Antagonisti
8-Fenil-1,3-dipropilksantin • Acefilin • Aminofilin • Bamifilin • Kofein • CGS-15943 • 8-Hloroteofilin • CPX • CVT-6883 • Dimetazan • DPCPX • Fenetilin • Istradefilin • KF-26777 • MRE3008F20 • MRS-1220 • MRS-1334 • MRS-1706 • MRS-1754 • MRS-3777 • Paraksantin • Pentoksifilin • Preladenant • Propentofilin • PSB-10 • PSB-11 • PSB 36 • PSB-603 • PSB-788 • PSB-1115 • Rolofilin • SCH-442,416 • SCH-58261 • Teobromin • Teofilin • VUF-5574 • ZM-241,385
Inhibitori preuzimanja
ENT inhibitori
VNT inhibitori