Ditolilgvanidin
IUPAC ime | |
---|---|
1,2-bis(2-methylphenyl)guanidine | |
Identifikatori | |
CAS broj | 97-39-2 Y |
ATC kod | none |
PubChem | CID 7333 |
ChemSpider | 7056 Y |
ChEMBL | CHEMBL282433 Y |
Hemijski podaci | |
Formula | C15H17N3 |
Molarna masa | 239.316 g/mol |
SMILES
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InChI
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Ditolilgvanidin je agonist sigma receptora.[1] On je selektivan za sigma receptore, ali nije selektivan između dva tipa sigma receptora, već se vezuje sa jednakim afinitetom za σ1 i σ2 .[2] On ima neuroprotektivne[3] i antidepresivne efekte,[4] i pojačava dejstvo NMDA antagonista.[5]
Vidi još
- Sigma receptor
Reference
- ^ Weber E, Sonders M, Quarum M, McLean S, Pou S, Keana JF (1986). „1,3-Di(2-(5-3H)tolyl)guanidine: a selective ligand that labels sigma-type receptors for psychotomimetic opiates and antipsychotic drugs”. Proc. Natl. Acad. Sci. U.S.A. 83 (22): 8784—8. PMC 387016 . PMID 2877462. doi:10.1073/pnas.83.22.8784.
- ^ Glennon, RA (2005). „Pharmacophore identification for sigma-1 (sigma1) receptor binding: application of the "deconstruction-reconstruction-elaboration" approach.”. Mini reviews in medicinal chemistry. 5 (10): 927—40. PMID 16250835.
- ^ Katnik, C; Guerrero, WR; Pennypacker, KR; Herrera, Y; Cuevas, J (2006). „Sigma-1 receptor activation prevents intracellular calcium dysregulation in cortical neurons during in vitro ischemia.”. The Journal of pharmacology and experimental therapeutics. 319 (3): 1355—65. PMID 16988055. doi:10.1124/jpet.106.107557.
- ^ Skuza, G; Rogóz, Z (2003). „Sigma1 receptor antagonists attenuate antidepressant-like effect induced by co-administration of 1,3 di-o-tolylguanidine (DTG) and memantine in the forced swimming test in rats.”. Polish journal of pharmacology. 55 (6): 1149—52. PMID 14730114.
- ^ Monnet, FP; Morin-Surun, MP; Leger, J; Combettes, L (2003). „Protein kinase C-dependent potentiation of intracellular calcium influx by sigma1 receptor agonists in rat hippocampal neurons.”. The Journal of pharmacology and experimental therapeutics. 307 (2): 705—12. PMID 12975497. doi:10.1124/jpet.103.053447.
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