Sigma receptor

Agonisti

• 4-PPBP
• Afobazol: selektivan za σ₁ tip
• Alilnormetazocin
• Amfetamin
• Citalopram
• Kokain
• Dekstrometorfan
• Dekstrorfan
• Dimetiltriptamin
• Dimemorfan
• Ditolilguanidin
• Escitalopram
• Fluoksetin
• Fluvoksamin
• Igmesin
• L-687,384: selektivan za σ₁ tip
• Lamotrigin - Antikonvulsant, bipolarna profilaksa^[4][5]
• Metamfetamin
• Morfin/Heroin
• Noscapin
• Opioidi: Oksikodon, Fentanil, itd.
• Opipramol
• Pentazocin: posebno „neprirodni“ enantiomer (+)-pentazocin, koji nema afinitet za opioidne receptore tako da je selektivan sigma agonist^[6][7]
• Pentoksiverin: selektivan za σ₁ tip
• Fenciklidin
• PB-28: selektivan za σ₂ tip
• PRE-084: selektivan za σ₁ tip
• SA 4503
• Siramesin

Antagonisti

• BD-1008
• BD-1047: selektivni σ₁ antagonist
• BD-1063
• BMY-14802
• CM156: 3-(4-(4-cikloheksilpiperazin-1-il)butil)benzo[d]tiazol-2(3H)-tion^[8]
• Haloperidol
• Rimkazol
• Sertralin^[9]

1. ^ Yang S, Bhardwaj A, Cheng J, Alkayed NJ, Hurn PD, Kirsch JR (2007). „Sigma receptor agonists provide neuroprotection in vitro by preserving bcl-2”. Anesth. Analg. 104 (5): 1179—84, tables of contents. PMC 2596726 . PMID 17456670. doi:10.1213/01.ane.0000260267.71185.73. 
2. ^ Fontanilla D, Johannessen M, Hajipour A, Cozzi N, Jackson M, Ruoho A (2009). „The Hallucinogen N,N-Dimethyltryptamine (DMT) Is an Endogenous Sigma-1 Receptor Regulator”. Science. 323 (5916): 934—937. PMC 2947205 . PMID 19213917. doi:10.1126/science.1166127. 
3. ^ Skuza G, Rogóz Z (2006). „The synergistic effect of selective sigma receptor agonists and uncompetitive NMDA receptor antagonists in the forced swim test in rats”. J. Physiol. Pharmacol. 57 (2): 217—29. PMID 16845227. 
4. ^ Calabrese JR; Suppes T; Bowden CL; et al. (2000). „A double-blind, placebo-controlled, prophylaxis study of lamotrigine in rapid-cycling bipolar disorder. Lamictal 614 Study Group”. The Journal of Clinical Psychiatry. 61 (11): 841—50. PMID 11105737. 
5. ^ Ng F, Hallam K, Lucas N, Berk M (2007). „The role of lamotrigine in the management of bipolar disorder”. Neuropsychiatric Disease and Treatment. 3 (4): 463—74. PMC 2655087 . PMID 19300575. 
6. ^ Maeda DY, Williams W, Bowen WD, Coop A (2000). „A sigma-1 receptor selective analogue of BD1008. A potential substitute for (+)-opioids in sigma receptor binding assays”. Bioorganic & Medicinal Chemistry Letters. 10 (1): 17—8. PMID 10636233. 
7. ^ Wu HE, Hong JS, Tseng LF (2007). „Stereoselective action of (+)-morphine over (-)-morphine in attenuating the (-)-morphine-produced antinociception via the naloxone-sensitive sigma receptor in the mouse”. European Journal of Pharmacology. 571 (2-3): 145—51. PMC 2080825 . PMID 17617400. doi:10.1016/j.ejphar.2007.06.012. 
8. ^ Xu YT; Kaushal N; Shaikh J; et al. (2010). „A novel substituted piperazine, CM156, attenuates the stimulant and toxic effects of cocaine in mice”. J. Pharmacol. Exp. Ther. 333 (2): 491—500. PMC 2872963 . PMID 20100904. doi:10.1124/jpet.109.161398. 
9. ^ Hashimoto, K (2009). „Sigma-1 Receptors and Selective Serotonin Reuptake Inhibitors: Clinical Implications of their Relationship” (PDF). Central Nervous System Agents in Medicinal Chemistry. 2009 (Sept): 197—204. 

• п
• р
• у