PRIM2
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| Primaza, DNK, polipeptid 2 (58kDa) | |||||||||||
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| Dostupne strukture | |||||||||||
| 3L9Q, 3Q36, 4BPU, 4BPW, 4BPX | |||||||||||
| Identifikatori | |||||||||||
| Simboli | PRIM2; PRIM2A; p58 | ||||||||||
| Vanjski ID | OMIM: 176636 MGI: 97758 HomoloGene: 731 GeneCards: PRIM2 Gene | ||||||||||
| EC broj | 2.7.7.- | ||||||||||
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| Pregled RNK izražavanja | |||||||||||
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| podaci | |||||||||||
| Ortolozi | |||||||||||
| Vrsta | Čovek | Miš | |||||||||
| Entrez | 5558 | 19076 | |||||||||
| Ensembl | ENSG00000146143 | ENSMUSG00000026134 | |||||||||
| UniProt | P49643 | P33610 | |||||||||
| Ref. Sekv. (iRNK) | NM_000947 | NM_008922.1 | |||||||||
| Ref. Sekv. (protein) | NP_000938 | NP_032948.1 | |||||||||
| Lokacija (UCSC) | Chr 6: 57.18 - 57.51 Mb | Chr 1: 33.45 - 33.67 Mb | |||||||||
| PubMed pretraga | [1] | [2] | |||||||||
Velika podjedinica DNK primaze je enzim koji je kod ljudi kodiran PRIM2 genom.[1][2]
Reference
- ↑ Shiratori A, Okumura K, Nogami M, Taguchi H, Onozaki T, Inoue T, Ando T, Shibata T, Izumi M, Miyazawa H, et al. (Feb 1996). „Assignment of the 49-kDa (PRIM1) and 58-kDa (PRIM2A and PRIM2B) subunit genes of the human DNA primase to chromosome bands 1q44 and 6p11.1-p12”. Genomics 28 (2): 350–3. DOI:10.1006/geno.1995.1155. PMID 8530050.
- ↑ „Entrez Gene: PRIM2A primase, polypeptide 2A, 58kDa”.
Literatura
- Stadlbauer F, Brueckner A, Rehfuess C, et al. (1994). „DNA replication in vitro by recombinant DNA-polymerase-alpha-primase.”. Eur. J. Biochem. 222 (3): 781–93. DOI:10.1111/j.1432-1033.1994.tb18925.x. PMID 8026492.
- Maruyama K, Sugano S (1994). „Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.”. Gene 138 (1–2): 171–4. DOI:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). „Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library”. Gene 200 (1–2): 149–56. DOI:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Coll JM, Hickey RJ, Cronkey EA, et al. (1998). „Mapping specific protein-protein interactions within the core component of the breast cell DNA synthesome”. Oncol. Res. 9 (11–12): 629–39. PMID 9563011.
- Schneider A, Smith RW, Kautz AR, et al. (1998). „Primase activity of human DNA polymerase alpha-primase. Divalent cations stabilize the enzyme activity of the p48 subunit”. J. Biol. Chem. 273 (34): 21608–15. DOI:10.1074/jbc.273.34.21608. PMID 9705292.
- Arezi B, Kirk BW, Copeland WC, Kuchta RD (1999). „Interactions of DNA with human DNA primase monitored with photoactivatable cross-linking agents: implications for the role of the p58 subunit”. Biochemistry 38 (39): 12899–907. DOI:10.1021/bi9908991. PMID 10504261.
- Smith RW, Nasheuer HP (2002). „Control of complex formation of DNA polymerase alpha-primase and cell-free DNA replication by the C-terminal amino acids of the largest subunit p180”. FEBS Lett. 527 (1–3): 143–6. DOI:10.1016/S0014-5793(02)03197-6. PMID 12220650.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Mungall AJ, Palmer SA, Sims SK, et al. (2003). „The DNA sequence and analysis of human chromosome 6”. Nature 425 (6960): 805–11. DOI:10.1038/nature02055. PMID 14574404.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Rush J, Moritz A, Lee KA, et al. (2005). „Immunoaffinity profiling of tyrosine phosphorylation in cancer cells”. Nat. Biotechnol. 23 (1): 94–101. DOI:10.1038/nbt1046. PMID 15592455.
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i inicijacija
Prokariotska (inicijacija) | |
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Eukariotska (priprema u G1 fazi) | Prereplikacioni kompleks: Kompleks prepoznavanja mesta početka (ORC1, ORC2, ORC3, ORC4, ORC5, ORC6) • Održavanje minihromozoma (MCM2 • MCM3 • MCM4 • MCM5 • MCM6 • MCM7) • CDC6 Autonomna replikaciona sekvenca Protein jednolančanog vezivanja (SSBP1, SSBP2, SSBP3) Primaza: PRIM1 • PRIM2 |
Oba | Početak replikacije/Ori/Replikon Replikaciona viljuška (zaostajući i vodeći lanci) • Okazakijev fragment • Prajmer |
Prokariotska (elongacija) | DNK polimeraza III holoenzim (dnaC, dnaE, dnaH, dnaN, dnaQ, dnaT, dnaX, holA, holB, holC, holD, holE) • Replizom • DNK ligaza • DNK stega • Topoizomeraza (DNK giraza) Prokariotska DNK polimeraza: DNK polimeraza I (Klenov fragment) |
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Eukariotska (sinteza u S fazi) | |
Oba |
B bsyn: dnk (repl, cycl, reco, repr) • tscr (fact, tcrg, nucl, rnat, rept, ptts) • tltn (risu, pttl, nexn) • dnab, rnab/runp • stru (domn, 1°, 2°, 3°, 4°)
