| TAF1 |
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| Наявні структури |
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| PDB | Пошук ортологів: PDBe RCSB |
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| Список кодів PDB | | 1EQF, 3AAD, 3UV4, 3UV5, 4RGW, 4YYM, 4YYN, 5I29, 5I1Q, 5FUR | | |
| Ідентифікатори |
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| Символи | TAF1, BA2R, CCG1, CCGS, DYT3, DYT3/KAT4, N-NSCL2, OF, P250, TAF(II)250, TAF2A, TAFII-250, TAFII250, XDP, MRXS33, TATA-box binding protein associated factor 1 |
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| Зовнішні ІД | OMIM: 313650 MGI: 1336878 HomoloGene: 37942 GeneCards: TAF1 |
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| Пов'язані генетичні захворювання |
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| X-linked dystonia-parkinsonism[1] |
| Онтологія гена |
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| Молекулярна функція | • transferase activity
• nucleotide binding
• DNA binding
• GO:0001105 transcription coactivator activity
• p53 binding
• transcription factor binding
• GO:0001948, GO:0016582 protein binding
• lysine-acetylated histone binding
• TBP-class protein binding
• acyltransferase activity
• ATP binding
• protein serine/threonine kinase activity
• histone acetyltransferase activity
• kinase activity
• protein heterodimerization activity
• H3K27me3 modified histone binding
• ubiquitin conjugating enzyme activity
• acetyl-CoA binding
• sequence-specific DNA binding
• RNA polymerase II core promoter sequence-specific DNA binding
• RNA polymerase II-specific DNA-binding transcription factor binding
• GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific
• GO:0000983 RNA polymerase II general transcription initiation factor activity
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| Клітинна компонента | • нуклеоплазма
• MLL1 complex
• клітинне ядро
• ядерце
• transcription regulator complex
• transcription factor TFIID complex
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| Біологічний процес | • фосфорилювання
• RNA polymerase II preinitiation complex assembly
• transcription by RNA polymerase II
• positive regulation of transcription initiation from RNA polymerase II promoter
• transcription, DNA-templated
• GO:0035404 peptidyl-serine phosphorylation
• DNA-templated transcription, initiation
• protein autophosphorylation
• клітинний цикл
• transcription initiation from RNA polymerase II promoter
• peptidyl-threonine phosphorylation
• positive regulation of proteasomal ubiquitin-dependent protein catabolic process
• GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II
• regulation of signal transduction by p53 class mediator
• GO:0022415 viral process
• histone acetylation
• protein polyubiquitination
• protein phosphorylation
• cellular response to DNA damage stimulus
• negative regulation of gene expression
• midbrain development
• positive regulation of protein binding
• cellular response to UV
• transcription factor catabolic process
• protein stabilization
• regulation of transcription initiation from RNA polymerase II promoter
• cellular response to ATP
• regulation of cell cycle G1/S phase transition
• negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding
• negative regulation of protein autoubiquitination
• negative regulation of ubiquitin-dependent protein catabolic process
• positive regulation of androgen receptor activity
• positive regulation of transcription by RNA polymerase I
• GO:0009373 regulation of transcription, DNA-templated
• negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage
• negative regulation of DNA-binding transcription factor activity
• ubiquitin-dependent protein catabolic process
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| Джерела:Amigo / QuickGO | |
| Шаблон експресії |
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| Більше даних |
| Ортологи |
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| Види | Людина | Миша |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (мРНК) | | NM_001286074
NM_004606
NM_138923 |
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| RefSeq (білок) | | NP_001273003
NP_004597
NP_620278 |
| | NP_001277658
NP_001392888
NP_001392889
NP_001392890
NP_001392891 |
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| Локус (UCSC) | Хр. X: 71.37 – 71.53 Mb | Хр. X: 100.58 – 100.65 Mb |
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| PubMed search | [2] | [3] |
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| Вікідані |
| Див./Ред. для людей | Див./Ред. для мишей |
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